Transcatheter ablation of atrioventricular junctional re-entrant tachycardia in children and adolescents in Hong Kong: comparison of cryothermal with radiofrequency energy

ABSTRACT

Hong Kong Med J 2012;18:207–13 | Number 3, June 2012
ORIGINAL ARTICLE
Transcatheter ablation of atrioventricular junctional re-entrant tachycardia in children and adolescents in Hong Kong: comparison of cryothermal with radiofrequency energy
Robin HS Chen, KT Wong, KS Lun, TC Yung
Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
OBJECTIVE. To compare the outcome of cryothermal and radiofrequency energy transcatheter ablation of atrioventricular junctional re-entrant tachycardia in children and adolescents.
 
DESIGN. Case series with internal comparison.
 
SETTING. Two hospitals in Hong Kong.
 
PATIENTS. Consecutive transcatheter ablation procedures for atrioventricular junctional re-entrant tachycardia in children and adolescents in our unit from August 2000 to September 2008 were retrospectively reviewed. Radiofrequency ablation was performed from August 2000 to June 2005, and cryoablation from July 2005 to September 2008.
 
MAIN OUTCOME MEASURES. Demographic data, outcome and procedural details.
 
RESULTS. Thirty-eight procedures were reviewed. The radiofrequency ablation group (n=20) and cryoablation group (n=18) had similar demographic characteristics, except that there were more patients with congenital heart disease in the latter group (P=0.03). Acute procedural success rate was 100% in both groups. One patient from the radiofrequency ablation group had recurrence of atrioventricular junctional re-entrant tachycardia. The frequency of post-ablation persistent heart block was higher in the radiofrequency ablation than cryoablation group (10% vs 0%, P=0.17), but this difference was not statistically significant. A shorter fluoroscopy time was noted in the cryoablation group (31 ± 13 vs 38 ± 18 minutes; P=0.03).
 
CONCLUSIONS. Transcatheter cryoablation for atrioventricular junctional re-entrant tachycardia in children and adolescents is as effective as radiofrequency ablation over the medium term. It has an excellent safety profile in terms of avoiding heart block.
 
Key words: Catheter ablation, radiofrequency; Cryosurgery; Tachycardia, atrioventricular nodal reentry
 
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Nurse-led hypertension referral system in an emergency department for asymptomatic elevated blood pressure

ABSTRACT

Hong Kong Med J 2012;18:201–6 | Number 3, June 2012
ORIGINAL ARTICLE
Nurse-led hypertension referral system in an emergency department for asymptomatic elevated blood pressure
Ludwig CH Tsoi, Cora CH Tung, Eliza LY Wong
Accident and Emergency Department, North District Hospital, Sheung Shui, Hong Kong
 
 
OBJECTIVES. To determine the characteristics of asymptomatic elevated blood pressure patients in an accident and emergency setting and assess the effect of a nurse-led intervention system.
 
DESIGN. Cross-sectional study.
 
SETTING. Accident and Emergency Department of a regional hospital in Hong Kong.
 
PARTICIPANTS. Patients with blood pressures of 140/90 mm Hg or above recorded twice (at triage and discharge) with no previous history of hypertension. Exclusion criteria were: (1) admission to hospital; (2) known hypertension; (3) referral for hypertension; (4) blood pressure higher than 180/120 mm Hg on rechecking.
 
INTERVENTION. Patients were issued a referral by the discharge nurse to follow-up for blood pressure monitoring in primary care.
 
MAIN OUTCOME MEASURES. Diagnosis of hypertension, follow-up rate, and risk factors of hypertension.
 
RESULTS. Of 245 patients with asymptomatic elevated blood pressure, we were able to contact 222 for follow-up, of whom 136 (61%) claimed to have been followed up for their blood pressure, and 48 (22%) were diagnosed to have hypertension. The nurse time for finding one case was 28 minutes. The projected impact could be large. If this simple nursing guideline is implemented territory-wide, more than 7000 new cases of asymptomatic hypertension might be picked up annually.
 
CONCLUSION. The implementation of a simple nurse-led hypertension referral system is a cost-effective way to screen asymptomatic subjects with elevated blood pressures in the accident and emergency department.
 
Key words: Blood pressure determination; Cardiovascular diseases; Hypertension; Preventive medicine; Primary health care
 
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Primary hyperaldosteronism among Chinese hypertensive patients: how are we doing in a local district in Hong Kong

ABSTRACT

Hong Kong Med J 2012;18:193–200 | Number 3, June 2012
ORIGINAL ARTICLE
Primary hyperaldosteronism among Chinese hypertensive patients: how are we doing in a local district in Hong Kong
WM Sy, SN Fu, W Luk, Carlos KH Wong, LM Fung
Department of Family Medicine and Primary Health Care, Kowloon West Cluster, Hong Kong
 
 
OBJECTIVES. To estimate the point prevalence of primary hyperaldosteronism in a government out-patient setting and to compare associated patient characteristics with those having essential hypertension.
 
DESIGN. Case series with external comparison.
 
SETTING. A single public hospital (Caritas Medical Centre) and all five associated general out-patient clinics in Sham Shui Po district in Hong Kong.
 
PATIENTS. All patients with confirmed primary hyperaldosteronism and randomly selected patients with essential hypertension from a medical specialist clinic and general out-patient clinics, retrieved from a computer database for the period January 2007 to December 2008.
 
MAIN OUTCOME MEASURES. Estimated point prevalence of primary hyperaldosteronism among hypertensive patients treated in the public sector of Sham Shui Po district. Patient age when hypertension was diagnosed, number of antihypertensive drugs used for treatment, and the presence of target organ damage in the patients with primary hyperaldosteronism and those with essential hypertension were compared.
 
RESULTS. Among the 46 012 patients receiving antihypertensive treatment, 49 were confirmed to have primary hyperaldosteronism. The estimated point prevalence of primary hyperaldosteronism among these hypertensive patients was 0.106% only, which was far smaller than figures from other countries. When compared with the 147 patients with essential hypertension by multivariate analysis, those with primary hyperaldosteronism were: (1) associated with longer durations of hypertension (odds ratio=1.14; 95% confidence interval, 1.06-1.24) despite being younger at the time of study, (2) likely to be taking three or more antihypertensive drugs (odds ratio=2.51; 95% confidence interval, 1.59-3.95), and (3) more likely to have left ventricular hypertrophy (odds ratio=5.01; 95% confidence interval, 1.83-13.69). All primary hyperaldosteronism patients studied presented with hypokalaemia. The need for antihypertensive drugs was markedly reduced after adrenalectomy for adrenal adenoma.
 
CONCLUSIONS. Primary hyperaldosteronism, which is potentially a surgically curable cause of hypertension, appeared to be underdiagnosed in our locality. Screening by aldosterone-renin ratio of high-risk individuals may help improve patient outcomes.
 
Key words: Adrenal cortex neoplasms; Aldosterone; Hyperaldosteronism; Hypertension; Prevalence
 
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Burnout among public doctors in Hong Kong: cross-sectional survey

ABSTRACT

Hong Kong Med J 2012;18:186–92 | Number 3, June 2012
ORIGINAL ARTICLE
Burnout among public doctors in Hong Kong: cross-sectional survey
Christina FY Siu, SK Yuen, Andy Cheung
Private practice, Hong Kong
 
 
OBJECTIVE. The stressful life of doctors makes them prone to burnout. We evaluated the prevalence of burnout among Hong Kong public hospital doctors and correlated burnout with job characteristics, working hours, stressors, and stress-relieving strategies.
 
DESIGN. Cross-sectional survey.
 
SETTING. Hong Kong.
 
PARTICIPANTS. One thousand doctors were randomly sampled from the Hong Kong Public Doctors' Association registry. Self-administered, anonymous questionnaires with postage-paid envelopes were mailed twice in early 2009. The Maslach Burnout Inventory-Human Services Survey was used for burnout assessment. According to this scale, burnout is defined as emotional exhaustion, depersonalisation, and a reduced sense of personal accomplishment. Correlation analysis, as well as univariate and multivariate analyses, were performed to assess factors associated with high degrees of burnout.
 
RESULTS. A total of 226 questionnaires were analysed, of which 31.4% of the respondents satisfied the criteria for high burnout. They were younger and needed to work shifts, and their median year of practice was 8.5. High-burnout doctors worked similar hours per week to non-high-burnout doctors (mean ± standard deviation, 56.2 ± 12.7 vs 54.7 ± 10.9; P=0.413) and reported suicidal thoughts more often (9.9% vs 2.6%; P=0.033). Moreover, 52.2% of high-burnout doctors were dissatisfied or very dissatisfied with their jobs. 'Excessive stress due to global workload' and 'feeling that their own work was not valued by others' were the most significant stressors associated with high emotional exhaustion and depersonalisation, while 'feeling that their own work was not valued by others' and 'poor job security' correlated with low personal accomplishment.
 
CONCLUSIONS. A high proportion of public doctors who responded to our survey endured high burnout. Trainees with some experience were at heightened risk. Stressors identified in this study should be addressed, so as to improve job satisfaction.
 
Key words: Burnout, professional; Depersonalization; Job satisfaction; Stress, psychological
 
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Is it feasible to discuss an advance directive with a Chinese patient with advanced malignancy? A prospective cohort study

ABSTRACT

Hong Kong Med J 2012;18:178–85 | Number 3, June 2012
ORIGINAL ARTICLE
Is it feasible to discuss an advance directive with a Chinese patient with advanced malignancy? A prospective cohort study
SY Wong, SH Lo, CH Chan, HS Chui, WK Sze, Y Tung
Department of Clinical Oncology, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
OBJECTIVES. Advance directives have been implemented for years in western countries, but the concept is new to Asian cultures. According to traditional Chinese culture, family members usually play a decisive role in a patient's treatment plan. Thus it may be hard to implement an advance directive despite its importance to the treatment of patients. The objectives of this study were to assess the feasibility of advance directive engagement and to explore significant contributing factors to achieving such a goal.
 
DESIGN. Prospective cohort study.
 
SETTING. Palliative Care Unit of Clinical Oncology, Tuen Mun Hospital, Hong Kong.
 
PATIENTS. The subjects of the investigation were adult patients diagnosed to have advanced malignancy and newly referred to the hospice service from 24 April 2009 to 30 July 2009. Data were collected from nursing assessment forms, locally designed advance directive forms, a checklist completed by oncologists, and details available in the electronic hospital record.
 
RESULTS. Of the 191 eligible patients, 120 (63%) had the advance directive, whereas 71 (37%) did not. In the Cox regression model, the patient having insight of a poor prognosis was the most significant factor facilitating advance directive engagement (P=0.001). Any family objection in the discussion of advance directives was also an important factor, though it did not reach statistical significance (P=0.082). Other factors like age, gender, education, religion, financial status, living environment, understanding the diagnosis, bereavement experience, type of cancer, nature of illness, courses of chemotherapy or radiotherapy received, main caregiver, in-house supporter, nurse-led clinic attendance, clinical psychologist consultation, and in-patient hospice nurse coordinator interview were all statistically insignificant.
 
CONCLUSIONS. Our study demonstrated that it was feasible to discuss an advance directive with Chinese patients with advanced malignancy. When patients have insight about their poor prognosis and family members have no objection, it may be appropriate to discuss an advance directive.
 
Key words: Advance care planning; Advance directives; Neoplasms; Patient self-determination act; Terminal care
 
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Epidemiology of occupational hand injury in Hong Kong

ABSTRACT

Hong Kong Med J 2012;18:131–6 | Number 2, April 2012
ORIGINAL ARTICLE
Epidemiology of occupational hand injury in Hong Kong
Rajesh Garg, Jason PY Cheung, Boris KK Fung, WY Ip
Department of Orthopaedics and Traumatology, University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam, Hong Kong
 
 
OBJECTIVES. To study the epidemiology of occupational hand injuries and associated social and industrial factors.
 
DESIGN. For this retrospective case series of patients with occupational hand injuries, case records were retrieved to gather data. In addition, all the subjects were interviewed by a single interviewer using a predesigned questionnaire.
 
SETTING. Division of Hand Surgery, Department of Orthopaedics and Traumatology, Queen Mary Hospital, Hong Kong.
 
PATIENTS. A total of 250 patients with occupational hand injuries were treated during the period from 1999 to 2001. This period was chosen to obtain 10 years of follow-up data to assess return to work and any secondary injuries.
 
MAIN OUTCOME MEASURES. Personal particulars (gender, age, marital status, education level, length of stay in Hong Kong, type of employment, wage system, personal habits, family size, number of breadwinners, income), type of industry and mode of injury, causes of injury according to the worker, work conditions, type of injury, and treatment given.
 
RESULTS. Two groups of workers in our study had more occupational hand injuries, namely those with less than 1 year of experience on a new job and immigrants from China. Factors associated with a large proportion of occupational hand injuries were male gender with personal risk factors (smoking and regular consumption of alcohol, long working hours), and in the case of machine operators, inadequate training and use of safety devices.
 
CONCLUSION. Occupational hand injuries lead to loss of working hours and compensation. For prevention, the workplace should be made into a safer and work-friendly environment. Workers should also have sufficient training.
 
Key words: Accidents, occupational; Hand injuries; Life style; Risk factors; Wounds and injuries
 
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The Chinese version of the pelvic pain and urgency/frequency symptom scale: a useful assessment tool for street-ketamine abusers with lower urinary tract symptoms

ABSTRACT

Hong Kong Med J 2012;18:123–30 | Number 2, April 2012
ORIGINAL ARTICLE
The Chinese version of the pelvic pain and urgency/frequency symptom scale: a useful assessment tool for street-ketamine abusers with lower urinary tract symptoms
CM Ng, WK Ma, KC To, MK Yiu
Division of Urology, Department of Surgery, Princess Margaret Hospital, Laichikok, Kowloon, Hong Kong
 
 
OBJECTIVE. To investigate the use of a translated Chinese version of the pelvic pain and urgency/frequency symptom scale as an assessment and prognostic tool to evaluate the severity of street-ketamine-associated lower urinary tract symptoms and their reversibility after abstinence.
 
DESIGN. Cross-sectional study.
 
SETTING. A special designated out-patient clinic in a regional hospital in Hong Kong.
 
PARTICIPANTS. There were 50 patients with street-ketamine-associated lower urinary tract symptoms and 20 healthy individuals.
 
MAIN OUTCOME MEASURES. Reliability and validity of the questionnaire; frequency of individual lower urinary tract symptoms, cystoscopic, urodynamic and radiological abnormalities, and their correlation with pelvic pain and the urgency/frequency score.
 
RESULTS. The test-retest reliability coefficient was 0.755 (P<0.001). Cronbach's alpha was 0.974. Mann-Whitney U test proved the discriminatory ability of the questionnaire (P<0.001). Patients with specific lower urinary tract symptoms had a higher mean pelvic pain and urgency/frequency total score compared to those without them: frequency (23.8 vs 17.3), nocturia (22.4 vs 14.0), urgency (22.5 vs 15.1), dysuria (22.7 vs 13.3), and haematuria (24.8 vs 16.2). The number of daytime voids and nocturia episodes correlated well with pelvic pain and urgency/frequency scores. With an increasing score, the likelihood of having cystitis changes, urodynamic abnormalities and hydronephrosis increased, while the cystometrically determined bladder capacity decreased. None of the patients with a score of 16 or below had urodynamic abnormality or hydronephrosis. The mean score change in the abstinence group was -4.33, versus +3.33 in their counterparts.
 
CONCLUSIONS. Theme Chinese version of the pelvic pain and urgency/frequency questionnaire is reliable and valid for assessment in patients with street-ketamine-associated lower urinary tract symptoms. The pelvic pain and urgency/frequency score correlates well with symptom severity as well as endoscopic, urodynamic and radiological abnormalities in patients with street-ketamine-associated lower urinary tract symptoms. A cut-off total pelvic pain and urgency/frequency score of 17 may suggest more serious urological sequelae from ketamine abuse. Abstinence from ketamine reduced lower urinary tract symptoms, but the extent of reversibility of urinary tract damage is yet to be evaluated.
 
Key words: Ketamine; Lower urinary tract symptoms; Questionnaires; Sensitivity and specificity; Substance-related disorders
 
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Acute and subacute inflammation of the optic nerve and its sheath: clinical features in Chinese patients

ABSTRACT

Hong Kong Med J 2012;18:115–22 | Number 2, April 2012
ORIGINAL ARTICLE
Acute and subacute inflammation of the optic nerve and its sheath: clinical features in Chinese patients
Andy CO Cheng, Noel CY Chan, Carmen KM Chan
Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong
 
 
OBJECTIVE. Inflammation of the optic nerve (optic neuritis) and its sheath (optic perineuritis) can have similar initial clinical presentations. They are less well-defined in the Chinese than in Caucasians, and the aetiology of optic neuritis may also differ depending on ethnicity. The aim of our study was to document the clinical features of acute/subacute optic neuritis/optic perineuritis in Chinese patients.
 
DESIGN. Retrospective case series.
 
SETTING. Hong Kong Eye Hospital, Hospital Authority.
 
PATIENTS. Records of all patients presenting to the Hong Kong Eye Hospital between 2005 and 2008, with their first episode of optic neuritis/optic perineuritis with onset of symptoms within 30 days, were reviewed.
 
MAIN OUTCOME MEASURES. Disease aetiology, clinical features and outcomes.
 
RESULTS. Twenty-nine patients were included (M:F=13:16), with a mean age of 46 years at presentation. Among these, 25 had optic neuritis and four had optic perineuritis; four presented with bilateral optic neuritis. Among the optic neuritis group, 17 (68%) were idiopathic, seven (28%) were related to multiple sclerosis, and one (4%) had neuromyelitis optica. Poor visual outcome in the optic neuritis group was associated with poor visual acuity at presentation and poor visual acuity at the nadir.
 
CONCLUSION. Optic perineuritis and neuromyelitis optica-related optic neuritis were more commonly encountered in our study of Hong Kong Chinese patients than in Caucasian populations. Even in Chinese patients with 'typical' optic neuritis, neuroimaging and further investigations may be warranted to exclude optic perineuritis/neuromyelitis optica, since Chinese ethnicity is itself an atypical feature. Where neuro-imaging is not readily available, intravenous methylprednisolone may be considered as initial treatment to cover both optic neuritis/optic perineuritis in patients with severe visual loss.
 
Key words: Multiple sclerosis; Optic nerve; Optic neuritis; Visual acuity
 
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Tight control early rheumatoid arthritis clinic in Hong Kong: a pilot study

ABSTRACT

Hong Kong Med J 2012;18:108–14 | Number 2, April 2012
ORIGINAL ARTICLE
Tight control early rheumatoid arthritis clinic in Hong Kong: a pilot study
Kitty Y Kwok, MH Leung
Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
 
 
OBJECTIVE. To evaluate disease activity in early rheumatoid arthritis patients in daily practice 1 year after applying a tight control treatment strategy aimed at lowering disease activity (Disease Activity Score 28, ≤3.2).
 
DESIGN. Single-arm open trial with historical controls.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. All new rheumatoid arthritis patients (onset <2 years) attending the tight control clinic from October 2008 to October 2009 were recruited. All the patients were followed up every 3 to 6 weeks and clinically assessed using the Disease Activity Score 28. Disease-modifying agent treatment was stepped up according to a preset protocol ladder and patient tolerance. The treatment target was to achieve a Disease Activity Score 28 of 3.2 or below (low disease activity). These patients were compared to matched historical controls in the rheumatology clinic.
 
RESULTS. Twenty patients in the tight control early rheumatoid arthritis clinic were recruited. Their disease activities were brought into better control than historical control patients who were followed up every 12 weeks. At week 52, clinical variables showed greater improvements in the intensive care group; respective mean scores (based on the Disease Activity Score 28 system) were 2.7 versus 4.2 (P<0.001); respective mean Health Assessment Questionnaire scores were 0.2 versus 1.3 (P<0.001).
 
CONCLUSIONS. Outcomes of patients attending our locally adapted tight control clinic were consistent with previous reports in the literature. The clinic reduced rheumatoid arthritis activity faster and better. It entailed more frequent follow-up and monitoring, however. To address this strategy more objectively, a randomised trial with parallel controls is necessary.
 
Key words: Antirheumatic agents; Arthritis, rheumatoid; Drug therapy, combination; Early diagnosis; Prognosis
 
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Factors influencing the mode of delivery and associated pregnancy outcomes for twins: a retrospective cohort study in a public hospital

ABSTRACT

Hong Kong Med J 2012;18:99–107 | Number 2, April 2012
ORIGINAL ARTICLE
Factors influencing the mode of delivery and associated pregnancy outcomes for twins: a retrospective cohort study in a public hospital
AL Liu, WK Yung, HN Yeung, SF Lai, MT Lam, FK Lai, TK Lo, WL Lau, WC Leung
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong
 
 
OBJECTIVES. To determine current trends for different modes of delivery in twin pregnancies, factors affecting the mode of delivery, and associated outcomes.
 
DESIGN. Retrospective cohort study.
 
SETTING. A public hospital in Hong Kong.
 
PARTICIPANTS. All twin pregnancies booked at Kwong Wah Hospital during a 3-year period from 1 April 2006 to 31 March 2009.
 
RESULTS. Of 197 sets of twins, 35 (18%) were delivered vaginally and 162 (82%) by caesarean section (47% were emergencies and 53% elective). In all, 32 (37%) of the elective and 21 (28%) of the emergency caesarean sections were in response to maternal requests. Vaginal delivery was more common in mothers with a history of vaginal delivery and monochorionic diamniotic twins. Women who conceived by assisted reproduction or those who had a tertiary education were more likely to deliver by caesarean section. The type of conception and the presentation of the second twin were statistically significant factors affecting maternal choice on the mode of delivery. Maternal age did not affect the choice of delivery mode. Except for the higher frequency of sepsis and cord blood acidosis in second twins delivered vaginally, there were no significant differences in neonatal morbidity between the groups that attempted vaginal delivery or requested caesarean sections. All the women who had compression sutures or hysterectomy to control massive postpartum haemorrhage were delivered by caesarean section.
 
CONCLUSION. A high caesarean section rate observed in our cohort was associated with maternal requests for this mode of delivery. The type of conception and the presentation of the second twin were statistically significant factors affecting maternal choice on mode of delivery. Women's requests for caesarean delivery out of the concern for their babies are not supported by current evidence. In response to a woman with a twin pregnancy requesting caesarean delivery, the pros and cons of vaginal deliveries and caesarean sections should be fully explained before the woman's autonomy is respected.
 
Key words: Cesarean section; Delivery, obstetric; Pregnancy, multiple; Reproductive techniques, assisted; Twins
 
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