Serial transverse enteroplasty for short bowel syndrome: Hong Kong experience

ABSTRACT

Hong Kong Med J 2012;18:35–9 | Number 1, February 2012
ORIGINAL ARTICLE
Serial transverse enteroplasty for short bowel syndrome: Hong Kong experience
Michael WY Leung, Ivy HY Chan, Nicholas SY Chao, Beatrice PY Wong, Kelvin KW Liu
Division of Paediatric Surgery, Department of Surgery, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong
 
 
OBJECTIVE. To report our experience with the first series of serial transverse enteroplasty operations (a novel bowel-lengthening procedure for patients with short bowel syndrome).
 
DESIGN. Case series.
 
SETTING. A tertiary paediatric surgery referral centre in Hong Kong.
 
PATIENTS. Four patients with short bowel syndrome aged 11 months to 14 years underwent serial transverse enteroplasty between November 2007 and June 2010.
 
RESULTS. A total of six such serial procedures were performed; two patients had repeated operations. Median pre-serial transverse enteroplasty small bowel length was 17.5 cm. The median increase in small bowel length was 90%. One patient experienced transient postoperative intestinal obstruction that resolved after conservative management. The median postoperative follow-up period was 31 months. The median enteral nutrition tolerance increased from 24% to 47%. The median weight-for-age z score increased by 0.55, and the median weight-for-height z score increased by 0.98. One patient had successfully weaned off parenteral nutrition.
 
CONCLUSION. Serial transverse enteroplasty is a feasible and safe treatment for short bowel syndrome patients, which helps to improve enteral nutrition and promote growth. Repeated serial transverse enteroplasty can be performed in patients with ultra-short bowel lengths. Follow-up is necessary to assess the long-term outcomes.
 
Key words: Intestinal obstruction; Intestine, small; Reconstructive surgical procedures; Short bowel syndrome
 
View this abstract indexed in MEDLINE:
 

Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap

ABSTRACT

Hong Kong Med J 2012;18:30–4 | Number 1, February 2012
ORIGINAL ARTICLE
Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap
TW Chiu, Czarina CH Leung, Edgar YK Lau, Andrew Burd
Plastic Reconstructive and Aesthetic Surgery, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To investigate gabapentin's role in head and neck cancer surgery following the demonstration of the effectiveness of gabapentin in reducing postoperative pain.
 
DESIGN. Non-randomised open-label trial.
 
SETTING. Prince of Wales Hospital, Hong Kong.
 
MAIN OUTCOME MEASURES. Pain scores, analgesic usage, and the frequency of adverse effects.
 
PATIENTS. In patients undergoing anterolateral thigh flap reconstruction after resection of tongue carcinoma, those who had an oral dose of gabapentin before surgery were compared to those who did not.
 
RESULTS. Postoperative pain was reduced in the gabapentin group (1.2) compared to the control group (1.7) [P=0.05]. In the gabapentin group, mean morphine (patient-controlled analgesia) use (3.5 mg), sedation scores (1.0), and antiemetic usage (0 mg metoclopramide) were all significantly reduced in comparison to the controls with respective figures of 11.4 mg, 1.6, and 12.2 mg.
 
CONCLUSION. Single preoperative doses of gabapentin led to significant reductions in postoperative pain and nausea with reduced analgesic and antiemetic usage, without additional side-effects or increases in operative complications.
 
Key words: Acetic acids; Analgesics; gamma-Aminobutyric acid; Head and neck neoplasms; Pain, postoperative
 
View this abstract indexed in MEDLINE:
 

Uses and abuses of paediatric electroencephalography

ABSTRACT

Hong Kong Med J 2012;18:25–9 | Number 1, February 2012
ORIGINAL ARTICLE
Uses and abuses of paediatric electroencephalography
WC Lee, SS Man, KW Lau, LC Cheng, NS Kwong, Karen L Kwong
Department of Paediatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
OBJECTIVE. To investigate whether requests for standard paediatric electroencephalograms accord with guideline recommendations, subsequent changes in clinical management according to reported results, and extent to which the service meets waiting time targets.
 
DESIGN. Case series.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. All patients aged less than 18 years who underwent electroencephalography between December 2009 and February 2010.
 
MAIN OUTCOME MEASURES. Appropriateness of the electroencephalogram request and the impact of its findings on clinical management.
 
RESULTS. A total of 109 patients were recruited, but requests for standard electroencephalograms were considered 'inappropriate' with respect to guidelines in 44% of the patients, of which 50% were made to diagnose 'funny turns'. The standard electroencephalogram contributed to the diagnosis or management in only 28% of patients. In all of the latter, the request for an electroencephalogram had been appropriate. Non-specialists made referrals for 86% of the patients. Inadequate information was provided in 66% of the requests. Standard electroencephalograms were performed within guideline targets, the wait being less than 4 weeks in 95% of requests.
 
CONCLUSION. An effective electroencephalogram service was being provided, though abuses were common. These were mainly because of misconceptions regarding the role and limitations of standard electroencephalograms. Through an educative, non-confrontational approach, and with time to explain guideline recommendations to clinicians, sustainable change in practice could be achieved so as to benefit patients, clinicians, and service provision.
 
Key words: Child; Electroencephalography; Hospitals, district; Practice guidelines as topic; Utilization review
 
View this abstract indexed in MEDLINE:
 

In-house human immunodeficiency virus-1 genotype resistance testing to determine highly active antiretroviral therapy resistance mutations in Hong Kong

ABSTRACT

Hong Kong Med J 2012;18:20–4 | Number 1, February 2012
ORIGINAL ARTICLE
In-house human immunodeficiency virus-1 genotype resistance testing to determine highly active antiretroviral therapy resistance mutations in Hong Kong
Jonathan HK Chen, KH Wong, Patrick CK Li, Kenny KC Chan, MP Lee, Sabrina WC To, WC Yam
Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong
 
 
OBJECTIVE. To determine the frequency of highly active antiretroviral therapy resistance mutations in the viral pol gene of human immunodeficiency virus-1 (HIV-1) genotypes that circulate in Hong Kong, by means of an in-house HIV-1 genotyping system.
 
DESIGN. Retrospective study.
 
SETTING. Two HIV clinics in Hong Kong.
 
PATIENTS. A modified in-house genotyping resistance test was used to sequence the partial pol gene in 1165 plasma samples from 965 patients. The performance of our test was cross-compared with the US Food and Drug Administration-approved ViroSeq HIV-1 genotyping system. The results of genotyping were submitted to the Stanford HIV-1 drug resistance database for analysis.
 
RESULTS. The cost-effective in-house genotypic resistance test (US$40) demonstrated comparable performance to the US Food and Drug Administration-approved ViroSeq system. The detection limit of this in-house genotypic resistance test could reach 400 copies/mL for both HIV-1 subtype B and CRF01_AE, which were the predominant genotypes in Hong Kong. Drug resistance mutations were detected only in post-treatment samples from treatment-failure patients. However, there was no significant difference in the frequency of drug resistance mutations between subtype B and CRF01_AE.
 
CONCLUSION. Our cost-effective in-house genotypic resistance test detected no significant difference in drug resistance-related mutations frequencies between HIV-1 subtype B and CRF01_AE in Hong Kong. A drug resistance-related mutations database for different HIV-1 genotypes should be established in Hong Kong to augment guidance for HIV treatment.
 
Key words: Antiretroviral therapy, highly active; HIV-1; Drug resistance, viral; Genotype; Mutation, missense
 
View this abstract indexed in MEDLINE:
 

Predictors of successful outcomes after external cephalic version in singleton term breech pregnancies: a nine-year historical cohort study

ABSTRACT

Hong Kong Med J 2012;18:11–9 | Number 1, February 2012
ORIGINAL ARTICLE
Predictors of successful outcomes after external cephalic version in singleton term breech pregnancies: a nine-year historical cohort study
LY Cho, WL Lau, TK Lo, Helen HT Tang, WC Leung
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, 25 Waterloo Road, Hong Kong
 
 
OBJECTIVE. To study the success rate, predictors for success, and pregnancy outcomes after external cephalic version.
 
DESIGN. Historical cohort study.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. All women who had singleton term breech pregnancies at term and opted for external cephalic version during 2001 and 2009. Their demographic data, clinical and ultrasound findings, procedure details, complications, and delivery outcomes were analysed.
 
MAIN OUTCOME MEASURES. Predictive factors for successful external cephalic version.
 
RESULTS. A total of 209 external cephalic versions were performed during the 9-year period. The success rate was 63% (75% for multiparous and 53% for nulliparous women). There was no significant complication. On univariate analysis, predictors of successful external cephalic version were: multiparity, unengaged presenting part, higher amniotic fluid index (≥10 cm), thin abdominal wall, low uterine tone, and easily palpable fetal head (subjective assessment by practitioners before external cephalic version). On multivariate analysis, only multiparity, non-engagement of the fetal buttock and thin maternal abdomen were associated with successful external cephalic version. In all, 69% of those who had successful external cephalic version succeeded in the first roll (P<0.001), and 82% of the women with successful external cephalic versions had vaginal deliveries (93% in multiparous and 69% in nulliparous women). Uptake rate of external cephalic version was studied in the latter part of the study period (2006-2009). Whilst 735 women were eligible for external cephalic version, 131 women chose to have the procedure resulting in an uptake rate of 18%.
 
CONCLUSION. External cephalic version was effective in reducing breech presentations at term and corresponding caesarean section rates, but the uptake rate was low. Further work should address the barriers to the low acceptance of external cephalic version. The results of this study could encourage women to opt for external cephalic version.
 
Key words: Breech presentation; Cesarean section; Version, fetal
 
View this abstract indexed in MEDLINE:
 

Cancellation of elective operations on the day of intended surgery in a Hong Kong hospital: point prevalence and reasons

ABSTRACT

Hong Kong Med J 2012;18:5–10 | Number 1, February 2012
ORIGINAL ARTICLE
Cancellation of elective operations on the day of intended surgery in a Hong Kong hospital: point prevalence and reasons
CH Chiu, Anna Lee, PT Chui
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. To determine the point prevalence of elective surgical case cancellations and the reasons.
 
DESIGN. Cross-sectional study.
 
SETTING. Teaching hospital, Hong Kong.
 
PATIENTS. Operating theatre records of elective surgery cancellations from 1 January 2009 to 31 December 2009 were retrospectively reviewed.
 
MAIN OUTCOME MEASURES. Cancellation of scheduled elective surgery on the day of surgery and the corresponding reasons.
 
RESULTS. Of 6234 cases scheduled, 476 were cancelled, which yielded a point prevalence of 7.6%, with a 95% confidence interval of 7.0-8.3%. The highest number of cancellations occurred in patients scheduled for major general surgical procedures (n=94, 20%), major urological procedures (n=64, 13%), major orthopaedic surgery (n=38, 8%), and ultra-major cardiothoracic surgery (n=29, 6%). The most common category for cancellation was facility (73%), followed by work-up (17%), patient (10%), and surgeon (1%). No available operating room time due to overrun of the previous surgery was the most common reason for case cancellation (n=310). Compared to general surgery, the odds of no available operating time was significantly less in orthopaedics (odds ratio=0.26; 95% confidence interval, 0.17-0.39), otolaryngology (0.25; 0.13-0.46), neurosurgery (0.36; 0.16-0.70), paediatrics (0.53; 0.31-0.87), gynaecology (0.18; 0.11-0.29), ophthalmology (0.19; 0.07-0.41), and dentistry (0.10; 0.00-0.60).
 
CONCLUSIONS. Case cancellations were mainly due to facility factors, such as no operating room time being available. The odds of having no operating room time available varied between surgical specialties.
 
Key words: Appointments and schedules; Efficiency, organizational; Operating rooms; Quality improvement; Surgical procedures, elective
 
View this abstract indexed in MEDLINE:
 

Secondary prevention of stroke: an evidence-based clinical audit in the primary care

ABSTRACT

Hong Kong Med J 2011;17:469–77 | Number 6, December 2011
ORIGINAL ARTICLE
Secondary prevention of stroke: an evidence-based clinical audit in the primary care
Catherine XR Chen, SL Chan, TC Law, SK Choi, KH Chan
Department of Family Medicine & GOPC, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
 
 
OBJECTIVE. To audit secondary preventive care in non-acute stroke patients in a local General Outpatient Clinic of the Hospital Authority.
 
DESIGN. Comparison of two samples from a case series at different time-points.
 
SETTING. General Outpatient Clinic, Hong Kong.
 
PATIENTS. Non-acute stroke patients fulfilling the inclusion criteria and regularly followed up in a local General Outpatient Clinic during the audit cycle were recruited. Evidence-based audit criteria and performance standards were established after thorough literature review. A sample from this case series was compared retrospectively at two time-points. First-phase evaluation was performed in October 2009 and deficiencies were identified. After 9 months of active intervention, second-phase evaluation was performed in July 2010. Chi squared test and student's t test were used to compare the significance of relevant changes noted.
 
RESULTS. First-phase data showed marked deficiencies in proper assessment of cardiovascular risk factors. Satisfactory blood pressure, glucose and lipid control was evident only in 47% of the hypertensive, 45% of the diabetic, and 37% of the dyslipidaemic stroke patients, respectively. After 9 months of implementing changes, significant improvements were noted with respect to standard targets being achieved. In the second phase, more comprehensive tackling of cardiovascular risk factors was noted, with satisfactory blood pressure control in 73% of hypertensive patients, and adequate metabolic control in 62% diabetic patients (P<0.01 for both). Only 59% of the dyslipidaemic stroke patients had optimal lipid control, though their mean low-density lipoprotein concentration was significantly reduced (P<0.05).
 
CONCLUSION. This study provided a valuable lesson in identifying deficiencies in secondary prevention for stroke patients managed in a local primary care facility. Using a team approach intervention, quality assurance was promoted and a definite impact on patient care was demonstrated.
 
Key words: Cardiovascular diseases; Guideline adherence; Hypertension; Secondary prevention; Stroke
 
View this abstract indexed in MEDLINE:
 

Single-incision laparoscopic cholecystectomy: from four wounds to one

ABSTRACT

Hong Kong Med J 2011;17:465–8 | Number 6, December 2011
ORIGINAL ARTICLE
Single-incision laparoscopic cholecystectomy: from four wounds to one
Jeff SW Wong, YS Cheung, KW Chan, Charing CN Chong, KF Lee, John Wong, Paul BS Lai
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
OBJECTIVE. To review the initial results and surgical outcomes of single-incision laparoscopic cholecystectomy.
 
DESIGN. Prospective case series.
 
SETTING. A university teaching hospital and a regional hospital in Hong Kong.
 
PATIENTS. All patients undergoing single-incision laparoscopic cholecystectomy from August 2009 to March 2011.
 
RESULTS. Fifty patients underwent single-incision laparoscopic cholecystectomy during the study period. The indications for surgery included symptomatic gallstones (n=43) and gallbladder polyps (n=7). The mean operating time was 78 (standard deviation, 24) minutes. Forty-five of the patients successfully underwent single-incision laparoscopic cholecystectomy, giving a success rate of 90%. In the remaining five patients, additional working ports were constructed to obtain better exposure and dissection around Calot's triangle. On comparing the results of the initial 25 cases to the subsequent 25 cases, in the latter group the operating time was significantly shorter (86 vs 71 minutes; P=0.02), and the success rate was higher (80% vs 100%; P=0.05). During the median follow-up period of 6.8 months, four patients had complications, which included: postoperative urinary retention (n=2), one each with a haematoma and an incisional hernia. No patient endured bile duct injury, postoperative bile leakage, or haemorrhage in our series.
 
CONCLUSION. Single-incision laparoscopic cholecystectomy is feasible and safe for treatment of uncomplicated gallbladder diseases. There was a reduction in the operating time and increase in success rate with accumulation of experience. Nevertheless, surgeons should be cautious about the potential risks of this new technique.
 
Key words: Cholecystectomy, laparoscopic; Cholelithiasis; Treatment outcome
 
View this abstract indexed in MEDLINE:
 

Development of the Chinese version of the Paediatric Allergic Disease Quality of Life Questionnaire: reliability and validity

ABSTRACT

Hong Kong Med J 2011;17:460–4 | Number 6, December 2011
ORIGINAL ARTICLE
Development of the Chinese version of the Paediatric Allergic Disease Quality of Life Questionnaire: reliability and validity
Daniel K Ng, Kenneth CW Wong, CH Chan, Eugene P Ng
Department of Paediatrics, Kwong Wah Hospital, Kowloon, Hong Kong
 
 
OBJECTIVE. Paediatric Allergic Disease Quality of Life Questionnaire is a health-related assessment tool designed for children with allergic diseases. This study aimed to translate the original English version of the Questionnaire to Chinese and to provide psychometric evidence on the validity and reliability of the translated version.
 
DESIGN. Cross-sectional study.
 
SETTING. Out-patient clinic of a non-teaching hospital in Hong Kong.
 
PARTICIPANTS. The Paediatric Allergic Disease Quality of Life Questionnaire was translated to Chinese and then completed by a group of 115 Hong Kong Chinese children (66 male and 49 female; mean age, 11 years) with allergic disease(s). All subjects were asked to respond using visual analogue scales dealing with issues related to the perceived morbidity of allergic diseases. To assess test-retest reliability, 2 weeks later a subgroup of 16 individuals was retested with the same Questionnaire.
 
RESULTS. The internal consistency of the Chinese Paediatric Allergic Disease Quality of Life Questionnaire was satisfactory (Cronbach alpha=0.92). The correlation between the total Questionnaire score and the visual analogue scale score was moderately significant (Spearman's rho=0.49; 95% confidence interval, 0.34-0.62). Structural validity as studied by confirmatory factor analysis found that the structure of subscales was remarkably similar to the original English version. The intra-class correlation between the Questionnaire score from the first and the second test in the subgroup of 16 subjects was 0.75, indicating adequate repeatability.
 
CONCLUSION. The validity and reliability of the Chinese version of the Paediatric Allergic Disease Quality of Life Questionnaire was established for clinical use.
 
Key words: Asthma; Child; Eczema; Quality of life; Rhinitis, allergic, perennial
 
View this abstract indexed in MEDLINE:
 

Intracranial electroencephalogram to evaluate refractory temporal and frontal lobe epilepsy

ABSTRACT

Hong Kong Med J 2011;17:453–9 | Number 6, December 2011
ORIGINAL ARTICLE
Intracranial electroencephalogram to evaluate refractory temporal and frontal lobe epilepsy
Lisa Au, Howan Leung, Patrick Kwan, XL Zhu, Danny TM Chan, HT Wong, WS Poon, Venus YH Tang, Sam KS Ng, Deyond Siu, Tom CY Cheung, PT Choi, KS Wong
Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVE. We undertook a collaborative study in a multidisciplinary team to channel refractory epilepsy patients to test a hypothesis about placement of intracranial electroencephalography arrays.
 
DESIGN. This was a descriptive case series. Prospective non-invasive presurgical evaluations were based on clinical semiology, magnetic resonance imaging, video-electroencephalography findings and neuropsychological assessments. If the results were discordant, a hypothesis was generated using individualised combinations of positron emission tomography, single-photon emission computed tomography, functional magnetic resonance imaging and Wada tests. The indications for intracranial electroencephalography were: (a) focal magnetic resonance imaging, ictal/interictal scalp electroencephalography with variable results (group A); (b) multi-focal magnetic resonance imaging, focal/multi-focal ictal scalp electroencephalography (group B); (c) non-lesional magnetic resonance imaging, focal/multi-focal ictal scalp electroencephalography (group C). We evaluated whether the seizure-onset zones and eloquent areas were delineated, surgical outcomes (if operated on), and pathology results.
 
SETTING. A tertiary referral centre for neurology in Hong Kong.
 
PATIENTS. A total of 105 refractory epilepsy patients completed non-invasive presurgical evaluations over the period 2007 to 2009. Thirty-two patients were eligible for direct resective surgery, and another 25 patients had a testing hypothesis formulated. Of these 25 patients, 10 were eligible for intracranial electroencephalography based on technical/financial considerations.
 
RESULTS. All 10 patients (group A=2, group B=4, group C=4) had their epileptogenic zones defined. Six patients underwent functional mapping, all of whom had their eloquent areas defined. Seven of the 10 patients underwent resective surgery; four of them achieved Engel class I/II outcomes. The dichotomised outcomes were 100% (group A), 50% (group B), and 33% (group C) achieving Engel class I/II. Two patients had asymptomatic subdural haematoma. There was no intracranial infection or operative mortality. In five (71%) of seven of the patients, a histological diagnosis was established.
 
CONCLUSION. Proper deployment of intracranial electroencephalography is useful in the presurgical evaluation of patients with refractory epilepsy. This modality of management is potentially of benefit for patients with refractory epilepsy, but is underutilised locally.
 
Key words: Electrodes; Electroencephalography; Epilepsy; Magnetic resonance imaging
 
View this abstract indexed in MEDLINE:
 

Pages