Prospective evaluation of seropositive occult hepatitis B viral infection in lymphoma patients receiving chemotherapy

ABSTRACT

Hong Kong Med J 2011;17:376–80 | Number 5, October 2011
ORIGINAL ARTICLE
Prospective evaluation of seropositive occult hepatitis B viral infection in lymphoma patients receiving chemotherapy
WI Cheung, SY Lin, Vincent KS Leung, Kitty SC Fung, YK Lam, FH Lo, TN Chau
Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong
 
 
OBJECTIVE. To serially evaluate the viral kinetics of occult hepatitis B virus infection in lymphoma patients and perform a correlation with clinical outcomes.
 
DESIGN. Case series with 1-year follow-up.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. Consecutive patients who were newly diagnosed to have lymphoma in the hospital between 1 April 2007 and 31 March 2008 were tested for hepatitis B (HB) surface (s) antigen (Ag), anti-HBs antibody (Ab) and anti-HB core (c) Ab. Seropositive occult hepatitis B patients as defined by being negative for HBsAg but positive anti-HBsAb and/or anti-HBcAb without a hepatitis B vaccination history were recruited. Serum HBsAg, anti-HBsAb, anti-HBcAb, hepatitis B virus deoxyribonucleic acid (DNA) level, and liver biochemistry were checked at baseline and every 4 weeks during and after chemotherapy until 12 months after the completion of chemotherapy or death. Entecavir was started if patients developed biochemical flare_up of hepatitis B associated with virological rebound. The prevalence and course of hepatitis B virus–related hepatitis, as well as any temporal relationship to viral kinetics and clinical hepatitis, were assessed.
 
RESULTS. Of 47 patients tested, 10 (21%) with lymphoma were seropositive occult hepatitis carriers. Their median baseline hepatitis B virus DNA level was 89 IU/mL (range, <34-807 IU/mL). Virological rebound (as defined by a 10-fold increase in serum hepatitis B virus DNA level from pre-chemotherapy level persisted for 4 weeks) occurred in one of the 10 patients, followed by biochemical reactivation. Whereupon entecavir treatment was started and no liver failure ensued. Regarding the other seropositive occult patients, their serum hepatitis B virus DNA levels fluctuated, but there was no associated biochemical reactivation.
 
CONCLUSION. Detectable baseline serum hepatitis B virus DNA is not uncommon in patients with occult hepatitis B who receive chemotherapy. Transient elevation in serum hepatitis B virus DNA levels does not predict biochemical reactivation, but antiviral treatment might be considered if virological rebound persists.
 
Key words: Chemotherapy, adjuvant; DNA, viral; Hepatitis B virus; Lymphoma, non- Hodgkin; T-lymphocytes, cytotoxic
 
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Trigger thumbs in children: results of surgical release

ABSTRACT

Hong Kong Med J 2011;17:372–5 | Number 5, October 2011
ORIGINAL ARTICLE
Trigger thumbs in children: results of surgical release
OY Leung, FK Ip, TC Wong, SH Wan
Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
OBJECTIVE. To evaluate results from surgical release of trigger thumbs in children in a regional hospital cluster in Hong Kong.
 
DESIGN. Descriptive case series.
 
SETTING. A regional hospital cluster, Hong Kong.
 
PATIENTS. Data from 1993 to 2009 on 180 children with 209 trigger thumbs were collected. Analyses into gender, predominance of thumb, age of onset, associated abnormalities and family history, symptoms and signs, surgical outcomes, and postoperative complications were carried out retrospectively.
 
RESULTS. There were 92 girls and 88 boys having trigger thumbs (1.05:1). In all, 29 (16%) of the children presented with bilateral trigger thumbs, while the right thumb was singly involved in 81 (45%) and the left thumb in 70 (39%) of the children. The mean age of onset was 19 months; only 20% were diagnosed before the age of 1 year. Only nine (5%) of the children were associated with congenital diseases and none had a positive family history of trigger thumb. Flexion deformity was the major presenting feature, other than triggering or pain. A nodule and flexion deformity were very commonly observed during physical examination. More than 95% of the operated thumbs with transverse incision acquired a good range of movement with a scarcely apparent scar. A residual flexion deformity was evident in only 4%, mostly in children who underwent surgical release under the age of 1 year.
 
CONCLUSION. Surgical release is recommended for children with trigger thumbs aged more than 1 year, which attains satisfactory results with minimal complications.
 
Key words: Bone diseases; Child; Congenital abnormalities; Thumb; Trigger finger disorder
 
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Use of nutritional health supplements and associated factors among parents with children at kindergartens in Hong Kong

ABSTRACT

Hong Kong Med J 2011;17:365–71 | Number 5, October 2011
ORIGINAL ARTICLE
Use of nutritional health supplements and associated factors among parents with children at kindergartens in Hong Kong
SY Leung, CM Lum
School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
OBJECTIVES. To estimate the prevalence of so-called nutritional health supplement consumption among kindergarten children; secondarily to explore potential factors associated with such consumption.
 
DESIGN. Cross-sectional, self-administered questionnaire survey.
 
SETTING. One kindergarten each in Hong Kong island, Kowloon, and the New Territories region.
 
SUBJECTS. Parents who had a child studying at the three sampled kindergartens in April 2010.
 
RESULTS. Of 951 sets of parents, 730 (77%) responded. Approximately 52% (95% confidence interval, 47-58%) of the respondents gave regular health supplements to their child. The commonest type of supplement given was cod fish oil (69%). Approximately 36% of the respondents did not know the upper limit dosage of their supplement. Parents of only 66% of regular health supplements consumers, compared to 75% of non-regular users, knew that there was an inherent risk from over-consumption (P=0.018). Parental beliefs that “It is useful/important for normal child development” (adjusted odds ratio=1.93; 95% confidence interval, 1.18-3.16; P=0.009), “It is useful/important for immune function” (1.79; 1.05-3.05; P=0.032) were associated with consumption of health such supplements.
 
CONCLUSION. There is high rate of health supplement consumption among healthy kindergarten children in Hong Kong. There are wrong beliefs from parents that health supplements are important for normal-growing children for their normal growth and body immunity. About one-third of parents has limited knowledge on potential side-effects of overdose and do not know the limit of consumption. Education on “Less (health supplement) is more (health)” is recommended.
 
Key words: Child, preschool; Dietary supplements; Health food; Minerals/administration & dosage; Vitamins/administration & dosage
 
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Colorectal cancer surgery of octogenarians in Hong Kong: who will survive?

ABSTRACT

Hong Kong Med J 2011;17:358–64 | Number 5, October 2011
ORIGINAL ARTICLE
Colorectal cancer surgery of octogenarians in Hong Kong: who will survive?
WH Li, Tommy CF Lau, KK Wong, Arthur WH Chan, MT Cheung
Department of Surgery, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong
 
 
OBJECTIVE. To assess the accuracy of the Association of Coloproctology of Great Britain and Ireland scoring system in predicting the 30-day mortality after surgery for colorectal cancer in Hong Kong elderly (aged 80 years or more) patients.
 
DESIGN. Early mortality outcome audit in a historical cohort.
 
SETTING. Queen Elizabeth Hospital, Hong Kong.
 
PATIENTS. All Chinese patients (aged 80 years or more) who underwent elective or emergency surgery for colorectal cancer in the Department of Surgery between January 2005 and December 2009.
 
MAIN OUTCOME MEASURES. Receiver operating characteristic curve analyses were used to estimate the predictive ability of the score.
 
RESULTS. In all, 180 patients with colorectal cancer were included in this review. The overall 30-day and hospital mortality rates were 29/180 (16%) and 31/180 (17%), respectively. The Association of Coloproctology of Great Britain and Ireland score was significantly higher among patients who died within 30 days (4.2 vs 3.1, P=0.0001), and was the only independent predictor for 30-day mortality by logistic regression (P=0.009; odds ratio=2.555; 95% confidence interval, 1.277-4.932). The mean score of this study population was 3.22 (median, 3.10), giving a predicted 30-day mortality rate of 16.0 to 17.4%, which corresponded with an observed 30-day mortality of 16.1% encountered in this study. The score had a significantly larger area under the curve for the 30-day mortality rates (odds ratio=0.811; 95% confidence interval, 0.722-0.849) as compared to the American Society of Anesthesiologists score (0.664; 0.589- 0.735) [P=0.0001].
 
CONCLUSION. The Association of Coloproctology of Great Britain and Ireland scoring system can accurately predict the 30-day mortality rate of elderly Hong Kong Chinese patients (aged 80 years or more) operated on for colorectal cancer.
 
Key words: Aged, 80 and over; Colectomy; Colorectal neoplasms; Survival rate
 
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Faecal occult blood screening: knowledge, attitudes, and practice in four Hong Kong primary care clinics

ABSTRACT

Hong Kong Med J 2011;17:350–7 | Number 5, October 2011
ORIGINAL ARTICLE
Faecal occult blood screening: knowledge, attitudes, and practice in four Hong Kong primary care clinics
Tammy KW Tam, KK Ng, CM Lau, TC Lai, WY Lai, Luke CY Tsang
Primary Care Research Team, Professional Development and Quality Assurance, Department of Health, Hong Kong
 
 
OBJECTIVES. To assess primary care patients for their awareness, knowledge, and attitude towards colorectal cancer and screening, to report on the uptake of faecal occult blood test screening and the results of screening, and explore predictors of screening uptake.
 
DESIGN. Cross-sectional study.
 
SETTING. Four primary care clinics in Hong Kong.
 
PATIENTS. A total of 1664 patients aged 50 to 74 years attending the clinics in the period July 2006 to July 2007.
 
MAIN OUTCOME MEASURES. Percentage of subjects who were aware that colorectal cancer is common and curable at an early stage, and who knew that faecal occult blood test or colonoscopy is useful for screening; relevant knowledge score; uptake rate of faecal occult blood testing; rate of testing positive; and factors predicting uptake.
 
RESULTS. A total of 1645 questionnaires were collected. In all, 89% (95% confidence interval, 88-91%) were aware that colorectal cancer is common, 95% (94-96%) believed faecal occult blood test and colonoscopy are useful for screening, and 58% (56-61%) achieved a knowledge score of 50% or above. The uptake rate of the faecal occult blood test was 35%. Uptake was higher among those with a positive family history (odds ratio=1.57; 95% confidence interval, 1.08-2.27; P=0.02), those who were more aware that colorectal cancer is common (1.86; 1.29-2.69; P=0.001), and that colorectal cancer is potentially curable at an early stage (1.76; 1.32-2.36; P=0.0001). Rate of testing positive was 2.1% (95% confidence interval, 0.9-3.3%); no colorectal cancer was detected and the neoplasia detection rate (for cancers and adenomas) was 5.1 per 1000 subjects screened.
 
CONCLUSIONS. Patients were aware that colorectal cancer is common in our community, and faecal occult blood test or colonoscopy is useful for screening. The uptake of screening was low, though relatively higher for those with a positive family history and greater awareness of the high frequency and potential for cure of colorectal cancer. Faecal occult blood test positivity rate was 2.1%, and neoplasia detection rate 5.1 per 1000 screened.
 
Key words: Colorectal neoplasms; Mass screening; Occult blood
 
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Treatment of patients with chronic obstructive pulmonary disease as practised in a defined Hong Kong community: a cross-sectional pilot survey

ABSTRACT

Hong Kong Med J 2011;17:306–14 | Number 4, August 2011
ORIGINAL ARTICLE
Treatment of patients with chronic obstructive pulmonary disease as practised in a defined Hong Kong community: a cross-sectional pilot survey
WC Yu, Emily LB Tai, SN Fu, KC Kwong, YC Yeung, Y Chang, YK Yiu, CM Tam
Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong
 
 
OBJECTIVES. To examine the characteristics of chronic obstructive pulmonary disease patients of the Kwai-Tsing area, Hong Kong, and the chronic treatments they received.
 
DESIGN. Cross-sectional survey.
 
SETTING. Four clinic settings in Hong Kong: Respiratory Specialist Clinic, Princess Margaret Hospital (group 1); Medical Specialist Clinics, Princess Margaret Hospital (group 2); General Outpatient Clinics, Princess Margaret Hospital (group 3); South Kwai Chung Chest Clinic, Department of Health (group 4).
 
PATIENTS. Thirty physician-diagnosed chronic obstructive pulmonary disease patients in each of the above groups with post-bronchodilator 1-second forced expiratory volume/forced vital capacity ratios of less than 70% predicted values, who had been followed up at any of the participating clinics for at least 6 months.
 
RESULTS. There were 111 male and nine female patients. The median age was 72.5 years and 79% had at least one medical co-morbidity. The mean duration of their chronic obstructive pulmonary disease was 9.8 years, and their mean post-bronchodilator 1-second forced expiratory volumes were 45% (for males) and 58% (for females) of predicted values. There were significantly fewer stage I and more stage IV patients in group 1. Influenza vaccination coverage within the previous 1 year was 54% and did not differ significantly between groups. Chronic obstructive pulmonary disease education was given significantly more often to group 1 patients. Short-acting beta agonists were used to treat all patients but long-acting bronchodilators and pulmonary rehabilitation were used almost exclusively in group 1. Overall, long-acting bronchodilators and pulmonary rehabilitation were offered to 16% and 5%, respectively, of those for whom these were indicated (according to international guidelines).
 
CONCLUSION. In general there was insufficient education and under-treatment for chronic obstructive pulmonary disease patients. Management of such patients warrants improvements by way of increased accessibility to structured education programmes, pulmonary rehabilitation programmes, long-acting bronchodilator drugs, and respiratory specialist care.
 
Key words: Airway obstruction; Forced expiratory volume; Lung diseases, obstructive; Pulmonary disease, chronic obstructive; Vital capacity
 
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Laparoscopic sacrocolpopexy for uterine and post-hysterectomy prolapse: anatomical and functional outcomes

ABSTRACT

Hong Kong Med J 2011;17:301–5 | Number 4, August 2011
ORIGINAL ARTICLE
Laparoscopic sacrocolpopexy for uterine and post-hysterectomy prolapse: anatomical and functional outcomes
Cindy MY Chan, Helen HX Liang, WW Go, William WK To, KM Mok
Department of Obstetrics and Gynaecology, United Christian Hospital, Kwun Tong, Hong Kong
 
 
OBJECTIVE. To evaluate the anatomical and functional outcomes following laparoscopic sacrocolpopexy in a local unit.
 
DESIGN. Retrospective case series.
 
SETTING. A regional hospital in Hong Kong.
 
PATIENTS. All women who underwent laparoscopic sacrocolpopexy for symptomatic uterine or post-hysterectomy prolapse from January 2003 to December 2008.
 
MAIN OUTCOME MEASURES. Anatomical outcomes, functional outcomes including complications.
 
RESULTS. A total of 31 patients were recruited. The success rate in treating apical vaginal wall prolapse was 100%. There were no recurrences of vault prolapse (defined as stage II or higher). Approximately 19% of women had anterior vaginal wall prolapse and 23% had urinary stress incontinence postoperatively; 6% had a second operation because of anterior vaginal wall prolapse. The rates of dyspareunia and constipation were low. The mean hospital stay was 4 (range, 2-11) days. Two patients sustained bladder injuries and one rectal injury resulting in a rectovaginal fistula. For three patients the procedure was converted to a laparotomy.
 
CONCLUSIONS. Laparoscopic sacrocolpopexy is feasible in our population and has a high success rate for treating apical vaginal wall prolapse. The incidence of complications was acceptable.
 
Key words: Laparoscopy; Pelvic organ prolapse/ surgery; Sacrococcygeal region; Surgical mesh; Treatment outcome
 
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Validation study of the Chinese Identification Pain Questionnaire for neuropathic pain

ABSTRACT

Hong Kong Med J 2011;17:297–300 | Number 4, August 2011
ORIGINAL ARTICLE
Validation study of the Chinese Identification Pain Questionnaire for neuropathic pain
Anne Chan, Steven Wong, PP Chen, TH Tsoi, Joseph Lam, WY Ip, CP Wong, Lawrence Wong, Vincent Mok
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
 
 
OBJECTIVES. For diagnosing neuropathic pain, a simple 6-item patient-completed identification pain questionnaire has been validated among Caucasians. We aimed to study the validity and reliability of this questionnaire among Hong Kong Chinese patients.
 
DESIGN. Questionnaire survey.
 
SETTING. Two pain clinics and two neurology clinics in Hong Kong.
 
PATIENTS. Patients with either neuropathic pain or nociceptive pain were recruited randomly from the four clinics. The patients completed the questionnaire themselves and the diagnosis of neuropathic pain and nociceptive pain was made by the pain specialists. We determined the optimal cutoff, positive and negative predictive values, sensitivity, specificity, the area under the receiver operating characteristic curve, and test-retest reliability of the translated version.
 
RESULTS. Among the 92 participants, 60 (65%) had neuropathic pain and 32 (35%) had nociceptive pain. At an optimal cutoff score of 3 or higher, the positive predictive value was 87% while the negative predictive value was 55%, and it correctly classified 71% of cases. The specificity and sensitivity were 81% and 65%, respectively. The area under the curve was 0.78 (P<0.001). Test-retest reliability in the 10 randomly selected patients showed a good intraclass correlation of 0.72.
 
CONCLUSION. The Chinese Identification Pain Questionnaire is a valid and reliable scale that may be used as an initial diagnostic tool for neuropathic pain among Hong Kong Chinese patients.
 
Key words: Neuralgia; Pain measurement; ROC curve; Reproducibility of results; Sensitivity and specificity
 
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Mercury exposure: the experience of the Hong Kong Poison Information Centre

ABSTRACT

Hong Kong Med J 2011;17:292–6 | Number 4, August 2011
ORIGINAL ARTICLE
Mercury exposure: the experience of the Hong Kong Poison Information Centre
KL Fan, CK Chan, FL Lau
Accident and Emergency Department, Queen Mary Hospital, Hong Kong
 
 
OBJECTIVES. To review the characteristics of the consultation about the management of mercury exposure and identify the controversial issues on the clinical management of individuals with a history of mercury exposure.
 
DESIGN. Descriptive case series.
 
SETTING. Hong Kong Poison Information Centre, Hong Kong.
 
PARTICIPANTS. Persons consulting the Hong Kong Poison Information Centre about individuals with possible or definitive mercury exposure.
 
MAIN OUTCOME MEASURES. Characteristics of the consultations, including: the demographics of affected individuals, source and reason for the consultation, tissue mercury levels, the source of mercury exposure, specific intervention if any, and clinical outcomes.
 
RESULTS. Forty-one consultations were analysed. Most consultations were from the public sector. Reasons of the consultation were very variable. Individuals with abnormal tissue mercury levels were uncommon. There was only one case of acute mercury poisoning. The majority of identified individuals were not subjected to specific interventions. Chelation therapy was given to three patients, but in one of them it was considered to be contra-indicated.
 
CONCLUSION. The management of mercury exposure is highly variable. Recommendations were made on the approach to an individual with potential mercury exposure or poisoning.
 
Key words: Mercury poisoning; Metals, heavy
 
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Small bowel enema use in an Asian population: our eleven years of local experience

ABSTRACT

Hong Kong Med J 2011;17:286–91 | Number 4, August 2011
ORIGINAL ARTICLE
Small bowel enema use in an Asian population: our eleven years of local experience
WH Luk, Peter SM Yu, Andrea WS Au-Yeung, Adrian XN Lo, Lily KM Wong
Department of Diagnostic Radiology and Organ Imaging, United Christian Hospital, Kwun Tong, Hong Kong
 
 
OBJECTIVE. To retrospectively analyse the outcome of patients who underwent investigation by small bowel enema in a local centre.
 
DESIGN. Case series.
 
SETTING. Regional hospital, Hong Kong.
 
PATIENTS. All patients referred for small bowel enema in a local hospital from 1 January 1999 to 31 December 2009 were identified; respective findings from imaging and clinical records were reviewed.
 
RESULTS. A total of 341 patients were referred for small bowel enema, of whom 289 successfully completed the examination. There were 211 patients whose small bowel enema findings were considered normal and 78 were regarded as abnormal. The sensitivity of this investigation was 73% and its specificity was 91%. The respective positive and negative predictive values were 66% and 93%.
 
CONCLUSIONS. The selection of patients by clinicians with specific indications for small bowel enema is essential for making effective use of small bowel enema as an investigative tool.
 
Key words: Enema; Intestinal obstruction; Intestine, small; Sensitivity and specificity
 
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