Does chronic radiation enteritis pose a diagnostic challenge? A report of three cases

ABSTRACT

Hong Kong Med J 2008;14:327-30 | Number 4, August 2008
CASE REPORT
Does chronic radiation enteritis pose a diagnostic challenge? A report of three cases
Abdulzahra Hussain, Hind Mahmood, Adrian Thomas, Claire Frazer, Shamsi El-Hasani
Department of General Surgery, Princess Royal University Hospital, Farnborough Common, BR6 8ND, Kent, United Kingdom
 
 
We present three cases of late radiation enteritis, all admitted through the accident and emergency unit and managed in the surgical department. All presented with acute symptoms. Two had abdominal pain, nausea, and vomiting and in these two cases, plain radiology and computed tomography scans demonstrated small bowel obstruction. Exploratory laparotomies confirmed chronic radiation damage to the small bowel. The affected areas were resected and anastomoses were performed. The postoperative course was uneventful. The other patient presented with bleeding per rectum and a colonoscopy with biopsy of the rectum confirmed proctitis and radiation enteritis. This patient was treated conservatively and responded well. The key factor needed for successful diagnosis and management of chronic radiation enteritis is a high index of suspicion leading to appropriate use of imaging.
 
Key words: Enteritis; Intestine, small; Radiation injuries
 
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Bilateral cervical spondylolysis in a young Chinese woman presenting with a neck injury

ABSTRACT

Hong Kong Med J 2008;14:324-6 | Number 4, August 2008
CASE REPORT
Bilateral cervical spondylolysis in a young Chinese woman presenting with a neck injury
Annie CW Tam, John LY Leung, KY Lau, PK Yee
Department of Radiology, Pamela Youde Nethersole Eastern Hospital, Chai, Hong Kong
 
 
Cervical spondylolysis is an uncommon entity. It is important to recognise its characteristic radiological features and differentiate it from acute cervical fractures or dislocations in patients with neck injuries. We report the relevant clinical and radiological findings seen in a young Chinese woman managed in our hospital after a neck injury who was ultimately diagnosed with bilateral cervical spondylolysis with spondylolisthesis at C6.
 
Key words: Spondylolisthesis; Spondylolysis; Tomography, X-ray computed
 
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Severe right heart failure in two patients with thyrotoxicosis

ABSTRACT

Hong Kong Med J 2008;14:321-3 | Number 4, August 2008
CASE REPORT
Severe right heart failure in two patients with thyrotoxicosis
Vicki HK Tam, LM Fung
Department of Medicine and Geriatrics, Caritas Medical Centre, Shamshuipo, Hong Kong
 
 
Congestive heart failure is a recognised complication of uncontrolled thyrotoxicosis but isolated right heart failure is rarely seen in association with thyrotoxicosis. Two cases of right heart failure associated with thyrotoxicosis are presented. In a 45-year-old man with right heart failure, investigations for all common secondary causes of right heart failure were negative. The only concurrent disease identified was thyrotoxicosis. The right heart failure subsided after treatment of the thyrotoxicosis. In a 36-year-old woman, the right heart failure had two underlying causes, thyrotoxicosis and an atrial septal defect. Treatment of thyrotoxicosis alone resulted in improvement of pulmonary hypertension and right heart failure. Thyrotoxicosis should be considered as a possible cause of pulmonary hypertension or isolated right heart failure.
 
Key words: Heart failure; Heart septal defects, atrial; Hypertension, pulmonary; Thyrotoxicosis
 
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Prenatal sonographic diagnosis of familial Holt-Oram syndrome associated with type B interrupted aortic arch

ABSTRACT

Hong Kong Med J 2008;14:317-20 | Number 4, August 2008
CASE REPORT
Prenatal sonographic diagnosis of familial Holt-Oram syndrome associated with type B interrupted aortic arch
KM Law, KT Tse
Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
 
 
We present a rare case of familial Holt-Oram syndrome diagnosed sonographically at 18 weeks of gestation. The foetus had serious bilateral upper limb malformations, a ventricular septal defect and a type B interrupted aortic arch, while the mother had bilateral upper limb malformations only. The pregnancy was terminated. A pathological and radiological examination of the foetus confirmed the prenatal sonographic findings. Although genetic investigation of TBX5 mutations was not available in our locality at the time of diagnosis, the geneticists made a clinical diagnosis of familial Holt-Oram syndrome. The clinical features of our case completely fulfilled the strict diagnostic criteria for the syndrome. The cardiac malformations most commonly associated with Holt-Oram syndrome are atrial or ventricular septal defects. To the best of our knowledge, a prenatal diagnosis of Holt-Oram syndrome in association with a type B interrupted aortic arch has not been reported in the English literature before.
 
Key words: Heart defects, congenital; Upper extremity deformities, congenital; Syndrome; Ultrasonography, prenatal
 
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A rare cutaneous fungal infection complicating bacterial necrotising fasciitis

ABSTRACT

Hong Kong Med J 2008;14:314-6 | Number 4, August 2008
CASE REPORT
A rare cutaneous fungal infection complicating bacterial necrotising fasciitis
CK Chen, SH Wan, SK Kou
Department of Orthopaedics and Traumatology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
We report a case of bacterial necrotising fasciitis complicated by the rare fungus Absidia corymbifera. Although this fungal infection is rare, the prognosis is poor and it therefore requires attention. Only 30 cases have been reported since 1874, and we are the first group to report this clinical scenario in our locality. Using a comprehensive journal review, we discuss the expected clinical course and optimal management.
 
Key words: Absidia; Fasciitis, necrotizing; Mucormycosis
 
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Primitive neuroectodermal tumour of the kidney: radiologic-pathological correlations

ABSTRACT

Hong Kong Med J 2008;14:240-3 | Number 3, June 2008
CASE REPORT
Primitive neuroectodermal tumour of the kidney: radiologic-pathological correlations
YW Chea, Rashi Agrawal, Angeline CC Poh
Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608
 
 
A primitive neuroectodermal tumour of the kidney is a rare malignancy. We report the computed tomographic features and the histopathological correlation of such a tumour occurring in a middle-aged man. Although the radiological appearance has significant overlap with other renal tumours, this tumour should be included in the differential diagnosis of a large renal mass in younger patients.
 
Key words: Kidney neoplasms; Neuroectodermal tumors, primitive, peripheral; Tomography, X-ray computed
 
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Multimodal computed tomography evaluation before thrombolysis in acute ischaemic stroke

ABSTRACT

Hong Kong Med J 2008;14:236-9 | Number 3, June 2008
CASE REPORT
Multimodal computed tomography evaluation before thrombolysis in acute ischaemic stroke
Thomas W Leung, Wynnie WM Lam, Simon CH Yu, Cecilia SF Leung, Yannie OY Soo, Lawrence KS Wong
Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
Currently, when stroke patients are offered thrombolytic therapy, their ischaemic stroke subtypes are usually unknown. Given the risk of haemorrhage that accompanies thrombolytic therapy, unselective (or undiscriminating) use of recombinant tissue plasminogen activator in patients without large-artery thromboemboli is potentially hazardous. Advances in computed tomography techniques have enabled the stroke pathophysiology to be quickly delineated by multimodal computed tomography without compromise in time for recombinant tissue plasminogen activator administration. Through description of the investigation of a typical stroke patient, we report how this technique is feasible in a regional hospital and may guide judicious use of recombinant tissue plasminogen activator.
 
Key words: Cerebral hemorrhage; Thrombolytic therapy; Tissue plasminogen activator; Tomography, X-ray computed
 
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Acute myocardial infarction found by multi-detector computed tomography ordered for suspected aortic dissection

ABSTRACT

Hong Kong Med J 2008;14:233-5 | Number 3, June 2008
CASE REPORT
Acute myocardial infarction found by multi-detector computed tomography ordered for suspected aortic dissection
Sherwin SW Lo, WK Kwok
Department of Radiology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
Urgent requests for contrast computed tomographic scans of the thorax are often performed for suspected aortic dissections and pulmonary embolisms, both of which have clinical features similar to those seen in acute myocardial infarction. We present two cases with computed tomographic scans showing decreased myocardial enhancement, suggestive of acute myocardial infarction, but no evidence of aortic dissection. Acute myocardial infarction was subsequently confirmed by coronary angiography.
 
Key words: Coronary angiography; Myocardial infarction; Tomography, X-ray computed
 
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Use of magnetic resonance imaging for detecting clinically and mammographically occult ductal carcinoma in situ

ABSTRACT

Hong Kong Med J 2008;14:229-32 | Number 3, June 2008
CASE REPORT
Use of magnetic resonance imaging for detecting clinically and mammographically occult ductal carcinoma in situ
Gladys Lo, Polly SY Cheung
Department of Diagnostic and Interventional Radiology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong
 
 
We report on two cases where breast magnetic resonance imaging examination changed clinical management. Breast magnetic resonance imaging is now recognised as an indispensable adjunctive examination to mammography and ultrasound. In each of the two cases described, breast magnetic resonance imaging revealed unsuspected, extensive, and mammographically and ultrasonologically occult, ductal carcinoma in situ. In each of these cases, planned breast conserving surgery was changed to mastectomy. The success of breast conservation treatment depends on removal of all tumour with clear margins at the time of surgery. Magnetic resonance imaging is now considered the most sensitive method for evaluating the extent of breast cancer. Breast magnetic resonance imaging has a very high sensitivity for invasive carcinoma (near 100%), and recent studies show its specificity in high-risk patients is between 93 and 99%. Magnetic resonance imaging may well be proven an important adjunctive examination in patients who have dense breasts or extensive fibrocystic change.
 
Key words: Breast neoplasms; Carcinoma, ductal, breast; Magnetic resonance imaging; Mammography
 
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A novel CASR gene mutation in an octogenarian with asymptomatic hypercalcaemia

ABSTRACT

Hong Kong Med J 2008;14:226-8 | Number 3, June 2008
CASE REPORT
A novel CASR gene mutation in an octogenarian with asymptomatic hypercalcaemia
Ronald CW Ma, CW Lam, WY So, Peter CY Tong, Clive S Cockram, CC Chow
Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
An increasing number of patients are diagnosed with primary hyperparathyroidism after having hypercalcaemia detected incidentally during routine biochemical screening. Many are asymptomatic at the time of diagnosis. An 80-year-old woman was found to have asymptomatic hypercalcaemia. Initial investigations suggested a diagnosis of primary hyperparathyroidism. Subsequent investigations revealed that, in fact, she had familial hypocalciuric hypercalcaemia. Direct DNA sequencing of the calcium-sensing receptor (CASR) gene confirmed that the patient was heterozygous for c.2501delC, a novel frame shift mutation predicted to cause loss of function of the CASR gene. Several other family members were subsequently found to carry the same mutation. Suspected cases of hypocalciuric hypercalcaemia should be confirmed by detection of mutations within the CASR gene. Establishing the correct diagnosis will enable the patient and family members to avoid unnecessary investigations or operations.
 
Key words: Hypercalcemia; Hyperparathyroidism; Receptors, calcium-sensing
 
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