Fourteen-year experience of human leucocyte antigen typing in cases of disputed parentage in Hong Kong

ABSTRACT

Hong Kong Med J 1997;3:369-72 | Number 4, December 1997
ORIGINAL ARTICLE
Fourteen-year experience of human leucocyte antigen typing in cases of disputed parentage in Hong Kong
BR Hawkins
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
 
 
Seventy-seven cases of disputed parentage were studied using the human leucocyte antigen system over a 14-year period in Hong Kong. Of these, 30 (39.0%) related to the amendment or verification of birth registration details, 20 (26.0%) were for divorce or affiliation proceedings, and 19 (24.7%) were related to overseas resident visa applications. An exclusion of parentage of at least one of the alleged parents was shown in 23 (29.9%) cases; none of the cases related to overseas resident visa applications showed an exclusion. The study illustrates that human leucocyte antigen testing is a very powerful tool in the elucidation of disputed parentage in Hong Kong.
 
Key words: HLA Antigens; Paternity; Sensitivity and specificity
 
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Morbidity patterns of persons waiting for infirmary care in Hong Kong

ABSTRACT

Hong Kong Med J 1997;3:362-8 | Number 4, December 1997
ORIGINAL ARTICLE
Morbidity patterns of persons waiting for infirmary care in Hong Kong
LW Chu, CKW Pei
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
 
 
Ageing of the Hong Kong population is associated with an increased prevalence of physical and mental disability. For persons with severe disability, infirmary care is needed. In the present study, the morbidity pattern of persons waiting for infirmary service in Hong Kong was studied. Two hundred and four consecutive Central Infirmary Waiting List persons were included in the study. Clinical assessment was based on history review and physical examination. The commonest diagnoses giving rise to severe disability in this population, 89.2% of whom were elderly (aged greater-than-or-equal65 years), in descending order of prevalence were stroke (40.2%), dementia (27.0%), proximal femoral fracture (7.4%), and parkinsonism (5.9%); 67.5% of subjects were dependent physically. For cognitive function, 87.3% had a subnormal Abbreviated Mental Test score of less-than-or-equal5. Approximately 80% had urinary incontinence and/or bowel incontinence. For the outcome of assessment, 93.6% needed infirmary care, while 6.4% did not. More adequate provision of infirmary beds, innovative medical, nursing, and social home-support programmes, and effective prevention and rehabilitation programmes for patients with these disabling diseases are urgently needed in Hong Kong.
 
Key words: Aged; Disability evaluation; Hong Kong; Morbidity; Outcome and process assessment (health care)
 
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Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis

ABSTRACT

Hong Kong Med J 1997;3:355-61 | Number 4, December 1997
ORIGINAL ARTICLE
Nasopharyngeal carcinoma: presenting symptoms and duration before diagnosis
AWM Lee, W Foo, SCK Law, YF Poon, WM Sze, SK O, SY Tung, WH Lau
Department of Radiotherapy and Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
 
 
This is a retrospective analysis of 4768 patients with undifferentiated or non-keratinising carcinoma of the nasopharynx who were treated during 1 January 1976 to 31 December 1985. The mean duration of symptoms before diagnosis was 8 months (range, 1-36 months for 95% of patients). A significant association between the duration of symptoms and the presenting stage was observed (P<0.001); 58% and 39% of stage I and stage V patients, respectively, reported as having had symptoms for less than 6 months. Of the later presenters (those having had symptoms for 6 months or longer), 89% were given a full course of radical megavoltage radiotherapy, but 6% were too advanced for any irradiation attempt. Consequently, the 10-year actuarial disease-specific survival was significantly higher among the early presenters: 48% versus 42% (P<0.001). The importance of early detection is emphasised.
 
Key words: Nasopharyngeal neoplasms/diagnosis; Outcome and process assessment (health care); Survival analysis
 
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Acute viral hepatitis in Hong Kong: a study of recent incidences

ABSTRACT

Hong Kong Med J 1997;3:261-6 | Number 3, September 1997
ORIGINAL ARTICLE
Acute viral hepatitis in Hong Kong: a study of recent incidences
TN Chau, ST Lai, JY Lai, H Yuen
Department of Medicine, Princess Margaret Hospital, 2-10 Princess Margaret Hospital Road, Laichikok, Kowloon, Hong Kong
 
 
Acute hepatitis patients admitted to a referral centre from January 1995 through December 1995 were studied to determine the seroprevalence of the hepatitis viruses and related risk factors. Of the 434 patients with acute viral hepatitis, the episodes due to hepatitis A, B, C, D, and non-A, non-B, non-C, (non-ABC) were 214 (49.3%), 163 (37.6%), 7 (1.6%), 0 (0%), and 50 (11.5%), respectively. Acute hepatitis A and non-ABC hepatitis commonly occur in late spring and early summer and are probably related to the intake of shellfish and travel to endemic areas. Approximately 60% of cases of symptomatic hepatitis B infection were acute exacerbations of chronic infection. Sexual exposure was the single most important risk factor for acute hepatitis B infection. The rarity of acute hepatitis C and D might be related to the low rate of intravenous drug use in our locality. Hepatitis E virus probably contributed significantly to the cases of non-ABC hepatitis. Further studies are needed to establish the importance of various causative agents of acute hepatitis in Hong Kong.
 
Key words: Hepatitis, viral, human; Risk factors, hepatitis
 
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Improved Papanicolaou smear reporting through the use of automated data entry

ABSTRACT

Hong Kong Med J 1997;3:256-60 | Number 3, September 1997
ORIGINAL ARTICLE
Improved Papanicolaou smear reporting through the use of automated data entry
GPS Yeoh, KW Chan, WY Ng
Histopathology Unit, Canossa Hospital, 1 Old Peak Road, Hong Kong
 
 
The implementation of an automated data entry and report generation system using an optical scanner and commercially available image processing program is described. This method could be easily adapted for use in other fields of medical research where the compilation of a large amount of repetitive data is involved, such as the filling in of questionnaires. Using an optical scanner for data entry improves the efficiency of report generation, thereby improving the turnaround time of reports. Reports are standardised and more easily understood by referring doctors. Data is also standardised and validated and is more amenable for quality assurance analysis, in the reminder service for patients, and gives a performance analysis of smear takers.
 
Key words: Papanicolaou smear; Cervical intraepithelial neoplasia; Primary prevention; Automatic data processing
 
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Intrathecal morphine for post-operative analgesia in patients with fractured hips

ABSTRACT

Hong Kong Med J 1997;3:250-5 | Number 3, September 1997
ORIGINAL ARTICLE
Intrathecal morphine for post-operative analgesia in patients with fractured hips
ASK Kwan, BB Lee, T Brake
Department of Anaesthesia, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Hong Kong
 
 
This prospective, randomised, double blind study examined the efficacy of intrathecal morphine for post-operative analgesia in Chinese patients undergoing surgery to repair fractured hips. There were a total of 40 American Society of Anesthesiologists physical status grade I to IV patients scheduled for surgery following a fractured neck of the femur. Patients were randomised to a control group in which they received subarachnoid plain 0.5% bupivacaine, 2.2 mL, and normal saline, 0.4 mL, giving a total volume of 2.6 mL, or to a study group in which they received plain 0.5% bupivacaine, 2.2 mL, and preservative-free morphine, 0.2 mg, diluted with normal saline to a total volume of 2.6 mL. Patients were monitored for up to 24 hours by staff blinded to group allocation. The level of pain was assessed by a visual analogue pain score and the time of first request for analgesia was noted. The results show the median pain-free period in the control group was nine hours (range, 2-24 hours), while it was 24 hours (range, 16-24 hours) in the morphine group, a significant difference (P<0.05). No major complications were reported. Intrathecal morphine is a useful technique for giving post-operative pain relief, especially in the elderly, in whom many other techniques cannot be safely used.
 
Key words: Anesthesia, spinal; Pain, postoperative; Hip fractures
 
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A survey of the long term outcome of elderly stroke survivors and the needs of their carers

ABSTRACT

Hong Kong Med J 1997;3:158-62 | Number 2, June 1997
ORIGINAL ARTICLE
A survey of the long term outcome of elderly stroke survivors and the needs of their carers
CK Mok, ST Lau, PM Leung, SY Wong, W Siu, SY Au
Department of Geriatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong
 
 
A survey was conducted to assess the long term outcome of 60 elderly stroke survivors (mean age, 81.7 years). Of these patients, 48% died within one year of discharge and 79% of the mortality occurred in the first six months. Patients discharged to institutions after the initial stroke had a significantly higher risk of death in one year (relative risk=1.47) compared with those who were discharged home. For those who survived for a mean period of 18.6months, 72% (21/29) were institutionalised. This group had significantly worse functional status and mobility compared with those who were living at home. The caring of elderly stroke patients was considered a heavy burden for most carers at home or in institutions and the need for medical and social support was great.
 
Key words: Survival rate, cerebrovascular disorders; Aged; Caregivers Outcome Assessment (health care)
 
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A review of laparoscopy and laparotomy in the management of tubal pregnancy

ABSTRACT

Hong Kong Med J 1997;3:153-7 | Number 2, June 1997
ORIGINAL ARTICLE
A review of laparoscopy and laparotomy in the management of tubal pregnancy
PM Yuen, MS Rogers, A Chang
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
 
 
A retrospective review was performed of all women who had undergone operation for a tubal pregnancy at the Prince of Wales Hospital, Hong Kong, from November 1992 to March 1994. One hundred and five patients were included-611 were managed by laparoscopy and 44 by laparotomy. There were no differences in age, parity, gestational age, frequency of previous ectopic pregnancy, or laparotomy between the two groups. Sixty per cent of patients in the laparotomy group had a diagnostic laparoscopy prior to the laparotomy. The laparoscopy group had a lower incidence of haemoperitoneum (45.9% vs 75.0%, P<0.05). There was no difference in the mean operating time. The laparoscopic approach was associated with a significant reduction in: intra-operative blood loss (46.7 76.8 mL vs 213.4 149.3 mL. P<0.001), post-operative analgesia requirement (odds ratio 0.08, 95% CI, 0.02-0.32), post-operative morbidity (odds ratio 0.27, 95% CI, 0.12-0.58), length of hospital stay (2.9 2.2 days vs 5.1 1.2days, P<0.001) and recuperation period (11.0 9.3days vs 21.7 8.5 days, P<0.001). Operative laparoscopy has the advantage of combining diagnostic and therapeutic procedures in a single operation, and is a better approach than laparotomy in the management of tubal pregnancy.
 
Key words: Pregnancy, tubal; Pregnancy, ectopic; Surgery, laparoscopic
 
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Acute appendicitis-a recent audit of an old problem

ABSTRACT

Hong Kong Med J 1997;3:149-52 | Number 2, June 1997
ORIGINAL ARTICLE
Acute appendicitis-a recent audit of an old problem
KM Chung, SW Lee, NH Chia, MT Cheung, ST Hwang
Department of Surgery, Queen Elizabeth Hospital, Wylie Road, Kowloon, Hong Kong
 
 
We conducted a retrospective review of all patients who had an appendicectomy performed at the Queen Elizabeth Hospital, Hong Kong, from January 1993 through December 1994. The diagnostic accuracy for true appendicitis was 74%. Nine per cent of patients had other pathologies, which also needed exploration. The diagnostic accuracy in female patients was 66%, compared with 82% for male patients (P<0.0001). Female patients aged between 15 to 40 years were diagnosed accurately 62% of the time, which has significantly lower than the rate for other female patients (P=0.016). the overall morbidity and mortality rates were 9.2% and 3%, respectively. Complicated appendicitis had a higher morbidity rate of 21%, compared with 9% for uncomplicated appendicitis (P<0.0001). Results for patients who were operated on the day of admission were compared with those who were operated on the day after admission. No significant difference in diagnostic accuracy (P=0.46), percentage of complicated appendicitis (P=0.7), and morbidity rate (P=0.8) was found.
 
Key words: Appendicitis; Appendectomy; Diagnosis, differential
 
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Recent changes in the pattern of hand injuries in Hong Kong: a regional hospital survey

ABSTRACT

Hong Kong Med J 1997;3:141-8 | Number 2, June 1997
ORIGINAL ARTICLE
Recent changes in the pattern of hand injuries in Hong Kong: a regional hospital survey
LK Hung, KY Choi, K Yip, J Chan, PC Leung
Accident and Emergency Department, Prince of Wales Hospital, Shatin, Hong Kong
 
 
Adult inpatients with injuries to the hand admitted to the Department of Orthopaedics and Traumatology of the Prince of Wales Hospital, Hong Kong, from June 1992 to May 1993 were surveyed (n=533). The causes of injury, mechanisms involved, and the nature of injuries were recorded. The injuries were further graded according to four different scales. It was found that 65% of the injuries were sustained at work, 15% in domestic environments, 7.6% during sports or recreational activities, and 6.5% in traffic accidents. Injuries caused by heavy machinery amounted to 26.7% and the electric saw was the second most common cause of injury accounting for 9.4% of injuries. Crush injuries occurred in 37.8%. The incidence of hand injury is estimated to be 600 per 100,000 population annually. The pattern of hand injuries bears some similarities and differences to published series. A comparison with data obtained in Hong Kong in the 1970s shows that major changes have occurred. We need continual surveillance of hand injury patterns.
 
Key words: Hand injuries; Injury severity score; Fractures, hand; Occupational safety; Treatment outcome
 
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