Hong Kong Med J 2000;6:184-9 | Number 2, June 2000
SEMINAR PAPERS--REPRODUCTION TECHNOLOGY
Microdeletions on the long arm of the Y chromosome and their association with male-factor infertility
C Briton-Jones, CJ Haines
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Significant advances in treatment have enabled previously infertile males to achieve fatherhood, when only a few years ago they would have had no chance of biological paternity. In contrast to the overall success of assisted reproduction, the aetiology of male-factor infertility is poorly understood. Recent studies have shown, however, that a significant proportion of men with severe infertility have microdeletions of the Y chromosome. Furthermore, reports have shown that male infants conceived through assisted reproductive techniques have inherited the same Y-chromosome microdeletion as their fathers. It has thus become important to screen men who are at risk of Y-chromosome microdeletions, as this will determine if counselling is needed prior to starting infertility treatment. This review examines the significance and limitations of the current understanding of Y-chromosome microdeletions in male infertility.
Key words: Infertility, male/genetics; Oligospermia/genetics; Sequence deletion; Sequence tagged sites; Y chromosome
View this abstract indexed in MEDLINE: