Maternal and obstetric factors of hepatitis B
immunisation failure in Hong Kong: a multicentre
prospective study: abridged secondary
publication
KW Cheung1, MTY Seto1, ASY Kan1, D Wong2, TKO Kou3, PL So4, WL Lau5, RMS Wong6, CP Lee1, EHY Ng1
1Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong
2Department of Obstetrics and Gynaecology, Pamela Youde Nethersole Eastern Hospital
3Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital
4Department of Obstetrics and Gynaecology, Tuen Mun Hospital
5Department of Obstetrics and Gynaecology, Kwong Wah Hospital
6Department of Paediatrics and Adolescent Medicine, The University of
Hong Kong
Viral load of 8 log10 copies/mL at 28 to 30 weeks
of gestation could be the optimal hepatitis B virus
DNA cutoff to predict immunoprophylaxis failure.
Starting antiviral treatment at 30 weeks could reduce
the viral load and hence the immunoprophylaxis
failure rate.