© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
Artificial intelligence for detection of intracranial haemorrhage on head computed tomography scans: diagnostic accuracy in Hong Kong
Jill M Abrigo, MD, FRCR; Ka-long Ko, MPhil; Qianyun Chen, MSc; Billy MH Lai, MB, BS, FHKAM (Radiology); Tom CY Cheung, MB ChB, FHKAM (Radiology); Winnie CW Chu, MB ChB, FHKAM (Radiology); Simon CH Yu, MB, BS, FHKAM (Radiology)
Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
Corresponding author: Dr Jill M Abrigo (firstname.lastname@example.org)
Introduction: The use of artificial intelligence (AI) to identify acute intracranial haemorrhage (ICH) on computed tomography (CT) scans may facilitate initial imaging interpretation in the accident and emergency department. However, AI model construction requires a large amount of annotated data for training, and validation with real-world data has been limited. We developed an algorithm using an open-access dataset of CT slices, then assessed its utility in clinical practice by validating its performance on CT scans from our institution.
Methods: Using a publicly available international dataset of >750 000 expert-labelled CT slices, we developed an AI model which determines ICH probability for each CT scan and nominates five potential ICH-positive CT slices for review. We validated the model using retrospective data from 1372 non-contrast head CT scans (84 [6.1%] with ICH) collected at our institution.
Results: The model achieved an area under the curve of 0.842 (95% confidence interval=0.791-0.894; P<0.001) for scan-based detection of ICH. A pre-specified probability threshold of ≥50% for the presence of ICH yielded 78.6% accuracy, 73% sensitivity, 79% specificity, 18.6% positive predictive value, and 97.8% negative predictive value. There were 62 true-positive scans and 22 false-negative scans, which could be reduced to six false-negative scans by manual review of model-nominated CT slices.
Conclusions: Our model exhibited good accuracy in the CT scan–based detection of ICH, considering the low prevalence of ICH in Hong Kong. Model refinement to allow direct localisation of ICH will facilitate the use of AI solutions in clinical practice.
New knowledge added by this study
- A deep learning–based artificial intelligence model trained on an international dataset of computed tomography (CT) slices exhibited good accuracy in the detection of intracranial haemorrhage (ICH) on CT scans in Hong Kong.
- Considering the 6% prevalence of ICH in our institution, and using a pre-specified probability threshold of ≥50%, the model detected 74% of ICH-positive scans; this outcome improved to 93% via manual review of model-nominated images.
- Considering the expected clinical applications, model refinement is needed to improve diagnostic performance prior to additional tests in a clinical setting.
- Our model may facilitate assessment of CT scans by physicians with different degrees of experience in ICH detection, an important aspect of real-world clinical practice.
Head computed tomography (CT) scans constitute the main imaging investigation during the evaluation of trauma and stroke; they are also important in the initial work-up of headache and other non-specific neurological complaints. In Prince of Wales Hospital of Hong Kong alone, >25 000 head CT scans were performed in 2019 during the clinical management of patients who presented to the Accident and Emergency Department. Computed tomography scans are composed of multiple cross-sectional images (ie, slices), which may be challenging to interpret. Typically, these scans are initially reviewed by frontline physicians prior to assessment by radiologists, and delays during the review process can be substantial. Thus, the timely recognition of an acute finding, such as intracranial haemorrhage (ICH), is limited by the competence and availability of frontline physicians.
The presence and location or type of ICH impacts the next clinical step, which can be further imaging investigations, medical management, or surgical intervention.1 Furthermore, a confirmation of ICH absence can also be useful in clinical management. For example, it can facilitate safe discharge from the hospital when appropriate; in patients with acute stroke, the absence of ICH is an important exclusion criterion that influences treatment selection.2
The use of artificial intelligence (AI) for ICH detection is a topic with global relevance considering its diagnostic impact and ability to optimise workflow, both of which have high practical value.3 4 In the accident and emergency department, AI can facilitate ICH detection in head CT scans during times when a radiologist is unavailable. Although there have been multiple reports of deep learning methods with high accuracy in the detection of ICH, the models in those reports were developed using in-house labelled training datasets and validated using a limited number of cases.3 5 6 7 8 Recently, the Radiological Society of North America (RSNA) publicly released >25 000 multi-centre head CT scans with slices that have been labelled with or without ICH by experts.9 Here, we developed a model using this RSNA dataset, then validated its performance on CT scans from our institution to determine its potential for clinical application in Hong Kong.
This study was approved by the Joint Chinese University of Hong Kong—New Territories East Cluster Clinical Research Ethics Committee (Ref No.: 2020.061). The model was developed from a publicly available dataset and validated on retrospectively acquired data from our institution. The requirement for patient consent was waived by the Committee given the retrospective design of the study and anonymisation of all CT scans prior to use.
The results of this diagnostic accuracy study are reported in accordance with the Standards for Reporting of Diagnostic Accuracy Studies guidelines.10
Public dataset: model development and internal validation
We acquired 25 312 head CT scans from four institutions in North and South America available in the RNSA open dataset,11 and were split into slices (each slice ≥5 mm thick), which were then randomly shuffled and annotated by 60 volunteer experts from the American Society of Neuroradiology. Each CT slice was labelled to indicate the presence and type of ICH. When present, ICH was classified according to its location, namely, intraparenchymal haemorrhage (IPH), subarachnoid haemorrhage (SAH), subdural haemorrhage (SDH), epidural haemorrhage (EDH), and intraventricular haemorrhage (IVH). The RSNA dataset comprised 752 807 CT slices, which were divided into a training subset (85%) and test subset (15%) for internal validation. Each subset consisted of approximately 86% negative ICH slices and 14% positive ICH slices, along with the following proportions of ICH subtypes: 4.8% IPH, 4.7%-4.8% SAH, 6.3% SDH, 0.4% EDH, and 3.4%-3.5% IVH.
The convolutional neural network (CNN) VGG (named after the Visual Geometry Group from the University of Oxford, United Kingdom) is an effective end-to-end algorithm for image detection.12 In this study, we adopted the VGG architecture with a customised output layer and loss function optimised for multi-label classification. To adjust for the low prevalence of ICH in the training set, each subtype’s logit outputs zi were concatenated as independent channels after a sigmoid output layer:
The performance of the CNN model was evaluated by binary cross-entropy loss and Sørensen–Dice loss13:
The loss functions were linearly combined with weighted values to produce the multi-label classification loss:
Where wi denotes the class prevalence weight, and α and β denote respective loss mix ratios. For simplicity, wi=1∕(n-1) for all subtype classes and wi=1 for ‘ANY’ was treated as an independent ICH class.
The model was trained with software written in our laboratory using the end-to-end open-source machine learning platform TensorFlow on an Nvidia Titan Xp graphics processing unit.
During internal validation (ie, slice-level performance for the detection of any type of ICH), the model achieved an area under the curve (AUC) of 0.912 (95% confidence interval [CI]=0.909-0.915) with sensitivity and specificity of 85% and 80%, respectively. Additionally, for the detection of specific types of ICH, the following AUC (95% CI) and sensitivity/specificity values were obtained: 0.860 (0.853-0.867) and 77%/88% for IPH, 0.835 (0.829-0.842) and 75%/82% for SAH, 0.850 (0.845-0.855) and 74%/83% for SDH, 0.813 (0.790-0.836) and 72%/80% for EDH, and 0.870 (0.861-0.879) and 79%/89% for IVH.
Prince of Wales Hospital dataset: external validation
The consecutive head CT scans of patients aged ≥18 years who underwent initial brain CT scans in the Accident and Emergency Department of Prince of Wales Hospital from 1 to 31 July 2019 were included, thereby simulating the point prevalence of ICH.
Head CT scans were acquired on a 64-slice CT scanner. Data analyses were conducted using reformatted 5-mm-thick slices, which can be accessed and viewed by physicians at all hospital workstations. DICOM (Digital Imaging and Communications in Medicine) images were de-identified prior to data analyses. The large volume of data was explored through the identification of relevant CT data using an automated program which selected scans with specific DICOM tags. Computed tomography scans performed for follow-up purposes or after recent intracranial surgery, as well as scans without radiologist reports, were excluded from the analysis.
We reviewed the corresponding radiology reports to determine the presence and type of ICH (IPH, SAH, SDH, EDH, or IVH). The CT scans were assessed by radiologists or senior radiology trainees; the corresponding reports were regarded as scan-level ground truth labels for analysis, consistent with their use as clinical reference standards in Hong Kong. Considering its rarity, EDH was grouped with and labelled as SDH, which has a similar appearance on CT. For scans with false-negative results, we performed post-hoc labelling of model-nominated CT slices. All scans were assessed prior to model construction; thus, the scan reports were established without knowledge of the AI results. Furthermore, all scans comprised the external validation dataset and constituted ‘unseen data’ for the model.
The diagnostic accuracies of the model for the detection of any type of ICH and each type of ICH were determined by calculation of the AUC with 95% CI, using DeLong et al’s method.14 To construct the confusion matrix during external validation, CT scans were classified as ICH-positive using a pre-specified probability threshold of ≥50%8; the corresponding sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. Additional probability thresholds were established to achieve 90% sensitivity and 90% specificity for the presence of any type of ICH. Statistical analysis was performed using R software (version 4.0.2; R Foundation for Statistical Computing, Vienna, Austria), and the threshold for statistical significance was set at P<0.05.
Figure 1 shows an example of the model output. The model report includes an overall probability for the presence of ICH (labelled ‘A’ in Fig 1). Additionally, the model selects five representative CT image slices which are likely to contain ICH (one such slice is labelled ‘B’ in Fig 1), along with the probability of each ICH type in each representative slice (labelled ‘C’ in Fig 1). All scans were successfully analysed by the model.
Figure 1. Sample model output, highlighting three types of information provided by the model. A: intracranial haemorrhage (ICH) probability; B: model-nominated image with possible ICH and corresponding slice number in the computed tomography (CT) scan; C: probability of each ICH type for the corresponding CT slice
Prince of Wales Hospital data and model validation
The Standards for Reporting of Diagnostic Accuracy Studies diagram and corresponding confusion matrix are shown in Figure 2. In total, 1372 head CT scans (84 [6.1%] with ICH) were included in the analysis. The distribution of ICH types is summarised in the Table.
Figure 2. Standards for the Reporting of Diagnostic Accuracy flowchart for external validation of the model using computed tomography (CT) scans from Prince of Wales Hospital. The confusion matrix is shown below the flowchart
Table. Distribution of computed tomography (CT) scans without and with intracranial haemorrhage in the Prince of Wales Hospital dataset (n=1372)
Diagnostic performance of scan-based detection for any type of intracranial haemorrhage
The model achieved an AUC of 0.842 (95% CI=0.791-0.894; P<0.001) for the identification of any type of ICH. Using a probability threshold of ≥50% for the presence of ICH, the accuracy, sensitivity, specificity, PPV, and NPV were 78.6%, 73%, 79%, 18.6%, and 97.8%, respectively. In total, 62 scans were true positive, 22 were false negative, 1017 were true negative, and 271 were false positive (Fig 2).
Among the 62 true-positive scans, the model output in two cases did not contain ICH-positive CT slices: 6-mm IPH in the pons (n=1) and trace SAH in a patient with multiple metastatic tumours (n=1). Figure 3 shows selected cases of model-nominated CT slices with subtle ICH.
Figure 3. Representative computed tomography slices from model outputs for selected true-positive scans showing small or subtle intracranial haemorrhage. Arrowheads have been added to indicate intracranial haemorrhage. (a) Haemorrhage within a cystic tumour; (b, d, and e) subarachnoid haemorrhage; (c) intraparenchymal haemorrhage; (f) subdural haemorrhage
Among the 22 false-negative scans, 19 had one type of ICH (6 IPH, 7 SAH, 5 SDH, and 1 IVH), two had two types of ICH (1 IPH+SAH and 1 SAH+SDH), and one had three types of ICH (IPH+SAH+IVH). In 16 scans, the model selected at least one ICH-positive CT slice which allowed correct reclassification (Fig 4). The remaining six scans with undetected ICH (Fig 5) comprised small midbrain IPH (n=1), trace SAH (n=3), and thin SDH/EDH (n=2). One of the three cases of undetected trace SAH was visualised on thin CT slices but not on thick CT slices.
Figure 4. Representative computed tomography slices from model outputs for false-negative scans showing intracranial haemorrhage. Arrowheads have been added to indicate intracranial haemorrhage. (a) Intraventricular haemorrhage; (b, c, f, g, h, and i) subarachnoid haemorrhage; (d, e, l, m, n, o, and p) intraparenchymal haemorrhage; (j and k) subdural haemorrhage
Figure 5. False-negative computed tomography scans with undetected intracranial haemorrhage. Arrowheads have been added to indicate intracranial haemorrhage. (a-e) Representative images of intracranial haemorrhage in thick computed tomography slices [(a) intraparenchymal haemorrhage; (b and d) subdural haemorrhage; (c and e) subarachnoid haemorrhage]. (f) Trace subarachnoid haemorrhage that was visible in reformatted coronal thin computed tomography slices but not thick computed tomography slices
A probability threshold of 20.4% yielded a sensitivity of 90% (40% specificity, 9% PPV, and 98.3% NPV), whereas a threshold of 65.7% yielded a specificity of 90% (64% sensitivity, 30% PPV, and 97.4% NPV), for the detection of ICH.
Diagnostic performance of scan-based detection for each type of intracranial haemorrhage
At a probability threshold of ≥50%, the following AUC (95% CI) and corresponding sensitivity/specificity were obtained for each type of ICH: 0.930 (0.892-0.968) and 4%/100% for IPH, 0.766 (0.684-0.849) and 12%/96% for SAH, 0.865 (0.783-0.947) and 75%/90% for SDH/EDH, and 0.935 (0.852-1.000) and 85%/93% for IVH.
In this study, we used a large international training dataset to construct a model for ICH detection, then conducted external validation using data from Hong Kong. To overcome the discrepancy between the training dataset (composed of CT slices) and the validation dataset (composed of CT scans), and considering our goal of clinical application, we designed a model that iteratively conducts assessments at the slice level to generate an overall probability at the scan level, then nominates the slices with the highest ICH probability for clinician evaluation. Furthermore, we performed validation using a point-prevalence approach to determine the diagnostic performance of the model in a real-world setting. Considering the 6% prevalence of ICH in our institution, and using a pre-specified probability threshold of ≥50%, the model detected 74% of ICH-positive scans; this outcome improved to 93% via manual review of model-nominated images.
Artificial intelligence for intracranial haemorrhage detection: research and reality
Multiple studies have successfully used AI for ICH detection via deep learning methods, typically involving variants of CNNs. For example, Arbabshirani et al5 (deep CNN, >37 000 training CT scans) reported an AUC of 0.846 on 342 CT scans; Chang et al4 (two-dimensional/three-dimensional CNN, 10 159 training CT scans) reported an AUC of 0.983 on 862 prospectively collected CT scans. Furthermore, Chilamkurthy et al3 (CNN, >290 000 training CT scans) reported an AUC of 0.94 on 491 CT scans; Lee et al7 (four deep CNNs, 904 training CT scans) reported an AUC of 0.96 on 214 CT scans. Finally, Ye et al8 (three-dimensional joint CNN-recurrent neural network, 2537 training CT scans) reported an AUC of 1.0 on 299 CT scans; Kuo et al6 (patch-based fully CNN, 4396 training CT scans) reported an AUC of 0.991 on 200 CT scans. Although these results demonstrate the high diagnostic performance that can be achieved using deep learning methods for ICH detection, the studies were conducted using in-house training datasets, which are laborious to produce and limit subsequent clinical applications. Moreover, the results may not be directly applicable to clinical practice, considering the limited number (generally <500) of CT scans during validation, as well as the effect of prevalence on sensitivity and specificity. Yune et al15 demonstrated this problem with a deep learning model that had an AUC of 0.993 on selected cases, which decreased to 0.834 when validated on CT scans collected over a 3-month period; notably, this is comparable with the AUC of our model. Thus, model performance in a real-world setting can reduce the risk of bias and serve as a better indicator of clinical relevance.16
Artificial intelligence for intracranial haemorrhage detection: our approach
The development of an AI model is the first step in a long process of clinical translation. In this study, we aimed to construct an algorithm that was reasonably comparable with radiologist performance, prior to further tests in a clinical setting. We recognise that our model is not an end-product; it constitutes an initial exploration of the potential for an international dataset–derived algorithm to be implemented in our institution. To avoid problems associated with the lack of an annotated dataset from Hong Kong, we utilised a dataset labelled by international experts, which is the most extensive open-access dataset currently available. However, the model achieved limited diagnostic accuracy, mainly because of type 1 error (ie, identification of false positives). The training dataset was composed of CT slices, whereas the model functioned at the CT scan level, iteratively assessing all slices to identify slices with highest ICH probability. If any slice identified in a single scan is considered positive, the model reports the CT scan as ‘ICH-positive’. Thus, any detection of false positives at the slice level will lead to amplification of the false-positive rate at the scan level. This strategy resulted in a low PPV (~19%) and a high NPV (~98%). To reduce the detection of false positives, we included a CT slice nomination feature in the model, which highlights CT slices with the highest probability of ICH. This facilitates manual review and reduces the black-box nature of the model.
Potential implications of artificial intelligence–detected intracranial haemorrhage in clinical practice
During validation, the model was tested using an ICH point–prevalence approach to elucidate the potential clinical implications of the classification outcomes. With respect to true positives, most ICH-positive scans were detected; most of these scans had large areas of ICH, which presumably could be easily identified by non-radiologists. However, in six cases, the model correctly nominated CT slices with small areas of ICH. In two cases, the nominated images did not have ICH, which could potentially have led to incorrect reclassification of the scan as a false positive.
Furthermore, there were many false positives. Such results may reduce physician confidence despite the correct interpretation of an ICH-negative scan; they may lead to overdiagnosis (with prolonged hospitalisation) or further investigations, such as a follow-up CT scan that involves additional radiation exposure.
With respect to false negatives, the model output includes a secondary mechanism of image review that allowed correct reclassification of 16 scans, increasing the rate of ICH detection from 74% to 93%. In five cases, ICH was conspicuous on the nominated images; in 11 cases, the nominated images displayed subtle ICH. In cases of subtle ICH, it is possible to overlook the trace amount of ICH on the nominated CT slice. The same problem may affect true-positive scans, which may be misclassified as false positives unless subtle ICH is recognised in the nominated image. Unfortunately, the model-generated probability of each type of ICH in each selected image did not facilitate the localisation of ICH.
Based on our primary clinical motivation to develop this model, we focused on CT scans with reformatted thick CT slices that can be viewed in all hospital workstations by non-radiologists. In practice, radiologists use dedicated imaging workstations to view sub-millimetre thin CT slices with greater sensitivity, which can display smaller or subtler pathologies. Thus, there is limited capacity for ICH detection in thick CT slices; this was highlighted in a case of trauma-related trace SAH, which was visible on thin CT slices but not thick CT slices. Subarachnoid haemorrhage is reportedly the most difficult type of ICH to interpret.17 In practice, a patient with a very small amount of isolated traumatic SAH would likely receive conservative treatment, and the pathology could reasonably await detection via radiologist assessment.
This study had some limitations. First, diagnostic accuracy would have been more comprehensively assessed using a larger number of CT scans or a longer point prevalence; however, we limited the assessment to CT scans collected over a 1-month period, considering the preliminary stage of model development. Second, the CT scans were assessed by radiologists and senior radiology trainees who may have different degrees of experience in ICH detection17; importantly, this limitation reflects the real-world setting where model deployment is intended. Finally, the model was specifically trained for the detection of ICH; it was not trained for the detection of other clinically significant non-ICH findings (eg, non-haemorrhagic tumours, hydrocephalus, or mass effect). The detection of these other pathologies will require dedicated models with customised training datasets.
In this study, we used a CT slice–based dataset to develop an algorithm for CT scan–based ICH detection; we validated the model using our institutional data with a point-prevalence approach, yielding insights regarding its utility in real-world clinical practice. Although the model demonstrated good accuracy, its diagnostic performance is currently limited to the intended clinical application. However, our results support further development of the model to improve its accuracy and incorporate a mechanism that can facilitate visual confirmation of ICH location. These modifications would enhance the interpretability of the deep learning model and would be useful for further evaluation of clinical applications.
Concept or design: JM Abrigo, KL Ko, WCW Chu, SCH Yu.
Acquisition of data: JM Abrigo, Q Chen, WCW Chu, BMH Lai, TCY Cheung.
Analysis or interpretation of data: All authors.
Drafting of the manuscript: JM Abrigo, KL Ko, Q Chen.
Critical revision of the manuscript for important intellectual content: All authors.
Acquisition of data: JM Abrigo, Q Chen, WCW Chu, BMH Lai, TCY Cheung.
Analysis or interpretation of data: All authors.
Drafting of the manuscript: JM Abrigo, KL Ko, Q Chen.
Critical revision of the manuscript for important intellectual content: All authors.
All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity.
Conflicts of interest
All authors have disclosed no conflicts of interest.
We thank our department colleagues Mr Kevin Lo for anonymising and downloading Digital Imaging and Communications in Medicine data, and we thank Mr Kevin Leung for preparing figures for this manuscript.
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
This research was approved by the Joint Chinese University of Hong Kong—New Territories East Cluster Clinical Research Ethics Committee (Ref No.: 2020.061). The requirement for patient consent was waived by the Committee given the retrospective design of the study and anonymisation of all computed tomography scans prior to use.
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