Extracellular CD147 as a diagnostic marker for defective acrosome reaction in asthenozoospermia and idiopathic infertility: abridged secondary publication
E Fok
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
  1. Sperm from patients with asthenozoospermia exhibits reduced motility and decreased induction of the acrosome reaction (AR), which may be associated with CD147 deficiency.
  2. CD147 plays an important role in fertilisation by regulating sperm motility and the AR.
  3. Recombinant CD147 treatment could improve sperm function and fertilisation outcomes in sperm from patients with asthenozoospermia.
  4. The soluble CD147 levels in seminal plasma and follicular fluid can serve as predictive markers for fertilisation rates and in vitro fertilisation outcomes.