Huperzine A in treatment of amyloid-β- associated neuropathology in a mouse model of Alzheimer disease: abridged secondary publication
Q Yuan1, ZX Lin1, W Wu2, WN Albert1, BCY Zee3
1 School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong
2 School of Biomedical Sciences, The University of Hong Kong
3 Division of Biostatistics JC School of Public Health and Primary Care, The Chinese University of Hong Kong
1. Huperzine A treatment resulted in a reduction of acetylcholinesterase activity in TgCRND8 Alzheimer disease mice.
2. Huperzine A, an acetylcholinesterase inhibitor for Alzheimer disease, could not inhibit GSK3β activity, and therefore did not facilitate prevention of amyloid precursor protein processing/amyloid-β generation in TgCRND8 mice