Adiponectin gene therapy for Alzheimer
disease in a mouse model: abridged secondary publication
RCL Ng1, M Jian1, LW Yick1, M Bunting1, JSC Kwan1, SK Chung2, KH Chan1
1 Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong
2 School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
1. Liver-specific expression of trimeric adiponectin
can cross the blood-brain barrier.
2. Overexpression of trimeric adiponectin can improve memory function.
3. Overexpression of trimer adiponectin enhances neuronal insulin sensitivity and reduces amyloid-β deposition.
4. Adiponectin suppresses Aβ-induced microglia activation and neuroinflammatory responses, exerting protective effects to neurons and synapses in an Alzheimer disease mouse model.
5. Adiponectin deficiency exacerbates microglia-mediated neuroinflammation in an Alzheimer disease mouse model.
2. Overexpression of trimeric adiponectin can improve memory function.
3. Overexpression of trimer adiponectin enhances neuronal insulin sensitivity and reduces amyloid-β deposition.
4. Adiponectin suppresses Aβ-induced microglia activation and neuroinflammatory responses, exerting protective effects to neurons and synapses in an Alzheimer disease mouse model.
5. Adiponectin deficiency exacerbates microglia-mediated neuroinflammation in an Alzheimer disease mouse model.