Modified Huang-Lian-Jie-Du-Tang and its combination with memantine for Alzheimer disease: an in vivo study (abridged secondary publication)
SSK Durairajan1,2, M Li1, SK Chung3, QB Han1, A Iyaswamy1, SG Sreenivasmurthy1, S Malampati1, AK Kammala1
1School of Chinese Medicine, Hong Kong Baptist University
2Department of Microbiology, School of Life Sciences, Central University of Tamil Nadu, Tiruvarur, India
3Beijing Normal University-Hong Kong Baptist University, United International College, Zhuhai, Guangdong Province, China
1. Huang-Lian-Jie-Du-Tang (HLJDT) is composed
of Rhizoma coptidis, Radix scutellariae, Cortex
phellodendri, and Fructus gardenia at the ratio
of 3:2:2:3. It is a famous traditional Chinese
medicine. We found that HLJDT increased the
amyloid-β (Aβ) load in an Alzheimer disease
mouse model owing to the APP-increasing effect
of baicalein, which is the main pure compound of
a constituent herb, Radix scutellariae.
2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.
3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.
2. In contrast, the modified HLJDT is composed of Rhizoma coptidis, Cortex phellodendri, and Fructus gardenia in the ratio of 4:2:4, and showed both memory-enhancing effect and Aβ-reducing effects in an Alzheimer disease mouse model.
3. Upon confirming the modified HLJDT's efficacy and safety profile in clinical trials, the modified HLJDT may be prescribed for treating Alzheimer disease.