Neuroprotective effects of oxyresveratrol on 6-hydroxydopamine on medial forebrain bundles in a rat model of Parkinson disease: abridged secondary publication
A Shah1,2, YS Ho3, KM Ng4, M Wang5, C Legido-Quigley2,6, RCC Chang1,7
1Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
2Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King’s College London, UK
3School of Nursing, Faculty of Health and Social Sciences, Hong Kong Polytechnic University
4Department of Chemistry, Faculty of Sciences, The University of Hong Kong
5School of Biological Sciences, Faculty of Sciences, The University of Hong Kong
6Steno Diabetes Center Copenhagen, Gentofte, Denmark
7State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong
1. Oxyresveratrol significantly minimises motor deficits examined by apomorphine-induced rotation test, cylinder asymmetric test, and rotarod test.
2. However, oxyresveratrol cannot significantly reduce the loss of dopaminergic neurons. This suggests that oxyresveratrol per se may not be sufficient to elicit full protection.