Neuroprotective effects of oxyresveratrol on
6-hydroxydopamine on medial forebrain bundles
in a rat model of Parkinson disease: abridged
secondary publication
A Shah1,2, YS Ho3, KM Ng4, M Wang5, C Legido-Quigley2,6, RCC Chang1,7
1Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
2Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King’s College London, UK
3School of Nursing, Faculty of Health and Social Sciences, Hong Kong Polytechnic University
4Department of Chemistry, Faculty of Sciences, The University of Hong Kong
5School of Biological Sciences, Faculty of Sciences, The University of Hong Kong
6Steno Diabetes Center Copenhagen, Gentofte, Denmark
7State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong
1. Oxyresveratrol significantly minimises motor
deficits examined by apomorphine-induced
rotation test, cylinder asymmetric test, and
rotarod test.
2. However, oxyresveratrol cannot significantly reduce the loss of dopaminergic neurons. This suggests that oxyresveratrol per se may not be sufficient to elicit full protection.
2. However, oxyresveratrol cannot significantly reduce the loss of dopaminergic neurons. This suggests that oxyresveratrol per se may not be sufficient to elicit full protection.