Nanoparticles to identify Alzheimer disease by
magnetic resonance imaging: abridged secondary publication
L Baum1, AHL Chow1, YX Wang2, EX Wu3, RG Pautler4
1School of Pharmacy, The Chinese University of Hong Kong
2Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong
3Department of Electrical and Electronic Engineering, The University of Hong Kong
4Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Texas, USA
1. We designed and tested an imaging material that
can be used to detect Alzheimer disease (AD) by
magnetic resonance imaging (MRI).
2. The material consists of magnetic iron nanoparticles coated with curcumin that binds the amyloid plaques in AD brain.
3. After injecting the nanoparticles, MRI distinguished AD from control model mice.
4. In examining slices of brains, the nanoparticles were highly concentrated at the plaques and significantly coincided with the dark spots seen on MRI.
5. The nanoparticles were non-toxic to cells grown in dishes.
2. The material consists of magnetic iron nanoparticles coated with curcumin that binds the amyloid plaques in AD brain.
3. After injecting the nanoparticles, MRI distinguished AD from control model mice.
4. In examining slices of brains, the nanoparticles were highly concentrated at the plaques and significantly coincided with the dark spots seen on MRI.
5. The nanoparticles were non-toxic to cells grown in dishes.