Maternal and obstetric factors of hepatitis B immunisation failure in Hong Kong: a multicentre prospective study: abridged secondary publication

Hong Kong Med J 2020;26(Suppl 6):S24-5

KW Cheung¹, MTY Seto¹, ASY Kan¹, D Wong², TKO Kou³, PL So⁴, WL Lau⁵, RMS Wong⁶, CP Lee¹, EHY Ng¹

¹Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong

²Department of Obstetrics and Gynaecology, Pamela Youde Nethersole Eastern Hospital

³Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital

⁴Department of Obstetrics and Gynaecology, Tuen Mun Hospital

⁵Department of Obstetrics and Gynaecology, Kwong Wah Hospital

⁶Department of Paediatrics and Adolescent Medicine, The University of Hong Kong

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Viral load of 8 log10 copies/mL at 28 to 30 weeks of gestation could be the optimal hepatitis B virus DNA cutoff to predict immunoprophylaxis failure. Starting antiviral treatment at 30 weeks could reduce the viral load and hence the immunoprophylaxis failure rate.