FE65 serine-610 phosphorylation and its functional implications in Alzheimer disease amyloid precursor protein processing
KF Lau1; WN Chow1; JCK Ngo1; YW Chen2; VKM Tam1; EHY Chan1; C Miller3
1 School of Life Sciences, The Chinese University of Hong Kong
2 Randall Division of Cell and Molecular Biophysis, King’s College London
3 Basic and Clinical Neuroscience, King’s College London
1. FE65 Serine610 (S610) phosphorylation regulates amyloid precursor protein (APP)/FE65 interaction and FE65-mediated APP processing.
2. FE65 S610 is phosphorylated by serum- and glucocorticoid-induced kinase 1.
3. The effect of FE65 S610 phosphorylation on APP processing is associated with the role of FE65 in metabolic turnover of APP via the proteasome.