Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma
HL Lung1, ML Lung2, S Law3
1 Department of Biology, Hong Kong Baptist University
2 Department of Clinical Oncology and Centre for Cancer Research, The University of Hong Kong
3 Department of Surgery, The University of Hong Kong
1. Serum amyloid A1 provides 100% sensitivity and 100% specificity for early detection of oesophageal squamous cell carcinoma. The choice of using serum or plasma samples is critical for circulating serum amyloid A detection.
2. The median survival time of patients with serum amyloid A1.3/1.5 genotype was shorter than that of patients with other genotypes (10.63 months vs 20.41 months, P=0.004). This was likely due to the extra high-circulating interleukin 6 concentrations.