B-1 cell response and its regulation during influenza virus infection
L Lu, X Wang, K Ma, M Chen, KH Ko, BJ Zheng
Department of Pathology and Centre of Infection and Immunology, The University of Hong Kong
1. Pleural cavity B-1a cells rapidly infiltrate lungs during influenza infection.
2. Pulmonary B-1a cells produce natural antibodies as first-line protection against influenza lung infection.
3. IL-17A deficiency impairs natural antibody production by B-1a cells.
4. IL-17A promotes B-1a cell differentiation into high-rate IgM producing cells in lung tissue.