DNA sequence patterns in human major histocompatibility
complex region in southern Chinese
YQ Song1; PS Sham2;
SP Yip3; YH Fan1; SY Bao1
1 School of Biomedical Sciences, The
University of Hong Kong
2 Department of Psychiatry, The
University of Hong Kong
3 Department of Health Technology &
Informatics, The Hong Kong Polytechnic University
1. We developed a programme, quantLD, for
genome-wide comparisons of linkage disequilibrium difference between two
populations and applied the methods to the major histocompatibility
complex region in 1000 Genomes Project phase 3 data. Results suggested
that linkage disequilibrium difference exists across populations.
2. We also developed a programme PyHLA for HLA alleles association analysis and applied to a set of 246 APOE ε4 allele negative Alzheimer disease cases and 172 normal controls. HLA-DRB1*07:01 and HLA-C*03 were inversely associated with Alzheimer disease, whereas HLA-DQB1*03:01 and DRB1*09:21 were associated with Alzheimer disease.
2. We also developed a programme PyHLA for HLA alleles association analysis and applied to a set of 246 APOE ε4 allele negative Alzheimer disease cases and 172 normal controls. HLA-DRB1*07:01 and HLA-C*03 were inversely associated with Alzheimer disease, whereas HLA-DQB1*03:01 and DRB1*09:21 were associated with Alzheimer disease.