Effect of combined use of Fructus Schisandrae and statin on high-fat-diet-induced metabolic syndrome in rats
E Wat1,2, CF Ng1,2, CL Liu1,2, C Zhang1,2, CM Koon1,2, CP Lau1,2, CW Wong1,2, KY Pang1,2, X Zhang1,2, KP Fung1,2,3, CBS Lau1,2, PC Leung1,2
1 Institute of Chinese Medicine, The Chinese University of Hong Kong
2 State Key Laboratory of Phytochemistry & Plant Resources in West China (CUHK), The Chinese University of Hong Kong
3 School of Biomedical Sciences, The Chinese University of Hong Kong
 
 
1. The combined use of Fructus Schisandrae aqueous extract (FSE) and atorvastatin (AS) exerts no further synergistic effect on diet-induced non-alcoholic fatty liver disease in rats, compared with rats given AS alone.
2. The use of FSE can protect high-fat-fed rats from AS-induced liver toxicity.
3. Preliminary pharmacokinetic studies suggest that FSE can enhance plasma metabolites of AS but reduce the liver metabolites of AS.