Identification of pathogenic microRNAs in Helicobacter pylori–associated gastric cancer using a combined approach of animal study and clinical sample analysis
CH Cho1,2, J Yu2, WKK Wu2
1 School of Biomedical Sciences, The Chinese University of Hong Kong
2 Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong
1. miR-490-3p is progressively down-regulated in the development of gastric cancer.
2. The tumour suppressive role of miR-490-3p is established both in vitro and in vivo.
3. DNA methylation is involved in the down-regulation of miR-490-3p in gastric cancer.
4. SMARCD1 is a direct target of miR-490-3p.