Detection of amyloid plaques in patients with post-stroke dementia
VCT Mok, WY Liu, A Wong
Department of Medicine and Therapeutics, The Chinese University of Hong Kong
Key Messages
1. Using 11C-Pittsburgh Compound B (PiB) positron emission tomography (PET), Alzheimer’s disease pathology was found in one-fifth of patients with post-stroke dementia.
2. Patients with Alzheimer’s disease pathology had a more progressive cognitive decline over 3 years after stroke or transient ischaemic attack.
3. In patients with post-stroke dementia, PiB PET may be used to guide treatment decision, as those with significant Alzheimer’s disease pathology may be more responsive to anti–Alzheimer’s disease drugs than those without.