Extracellular CD147 as a diagnostic
marker for defective acrosome reaction in
asthenozoospermia and idiopathic infertility:
abridged secondary publication
E Fok
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
- Sperm from patients with asthenozoospermia exhibits reduced motility and decreased induction of the acrosome reaction (AR), which may be associated with CD147 deficiency.
- CD147 plays an important role in fertilisation by regulating sperm motility and the AR.
- Recombinant CD147 treatment could improve sperm function and fertilisation outcomes in sperm from patients with asthenozoospermia.
- The soluble CD147 levels in seminal plasma and follicular fluid can serve as predictive markers for fertilisation rates and in vitro fertilisation outcomes.