Hong Kong Med J 2023;29(Suppl 3):S36-40
Weight loss versus continuous positive airway pressure therapy for obstructive sleep apnoea on metabolic profile stratified by craniofacial restriction: abridged secondary publication
SSS Ng1, J Woo1, P Cistuilli2, RWW Lee3, JKT Wong4, DSC Hui1
1 Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Department of Sleep Medicine, University of Sydney, Sydney, New South Wales, Australia
3 Department of Respiratory and Sleep Medicine, Gosford Hospital, Gosford, New South Wales, Australia
4 Department of Imaging and Interventional Radiology, Prince of Wales Hospital, Hong Kong SAR, China
 
 
  1. Weight loss by lifestyle modification programme (LMP) achieved more reduction in subclinical inflammation than continuous positive airway pressure (CPAP) therapy at 6 months among obese patients with moderate to severe obstructive sleep apnoea (OSA).
  2. Weight loss by LMP improved insulin sensitivity better than CPAP therapy at 6 months among obese patients with moderate to severe OSA, with smaller proportion of patients having abnormal glucose regulations by 6 months (46.1% vs 63.6%).
  3. Baseline sleep apnoea severity was associated with neck circumference, mandibular length, maxillary angle, and mandibular angle.
  4. Changes of subclinical inflammation and insulin sensitivity were not significantly different between patients with different degrees of craniofacial restriction.
  5. Only weight loss was associated with the percentage change of apnoea-hypopnoea index at 6 months.