Hong Kong Med J 2002;8:172-6 | Number 3, June 2002
Evaluation of a new handheld biosensor for point-of-care testing of whole blood beta-hydroxybutyrate concentration
RWK Chiu, CS Ho, SF Tong, KF Ng, CW Lam
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
OBJECTIVES. To evaluate performance characteristics of the newly available handheld combined glucose and ketone meter for beta-hydroxybutyrate measurement.
DESIGN. Laboratory method evaluation.
MAIN OUTCOME MEASURES. Accuracy of beta-hydroxybutyrate measurement and effect of acetoacetate interference at clinically important beta-hydroxybutyrate levels.
RESULTS. Deming regression analysis of beta-hydroxybutyrate measurements assessed by the ketone sensor and a laboratory enzymatic method revealed a coefficient of determination of 0.989 (P
CONCLUSION. The analytical performance of the sensor, when operated according to manufacturer’s instructions, could meet the needs of point-of-care beta-hydroxybutyrate measurement. Additional clinical studies are needed to assess the benefits of introducing such an assay in a clinical setting.
Key words: 3-Hydroxybutyric acid; Ketones; Point-of-care systems
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