Hong Kong Med J 2000;6:368-74 | Number 4, December 2000
Comparison of two dosages of recombinant human follicle-stimulating hormone in Chinese women undergoing controlled ovarian stimulation: prospective randomised double-blind study
EHY Ng, WSB Yeung, PC Ho
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
OBJECTIVE. To compare two dosages of recombinant human follicle-stimulating hormone for controlled ovarian stimulation. DESIGN. Prospective, randomised double-blind study.
SETTING. Tertiary assisted reproduction unit, Hong Kong.
PARTICIPANTS. Forty subfertile Chinese women aged 24 to 38 years undergoing in vitro fertilisation. Entry criteria included good physical and mental health, and a body mass index between 18 and 29 kg/square m. Exclusion criteria were subfertility caused by an endocrine abnormality, polycystic ovarian syndrome, or absent ovarian function; previous assisted reproduction treatment in which fewer than three oocytes were retrieved; prior hospitalisation due to severe ovarian hyperstimulation syndrome; chronic cardiovascular, hepatic, renal, or pulmonary disease; alcohol or drug abuse; and the administration of investigational drugs within the previous 3 months.
INTERVENTION. Injection of recombinant follicle-stimulating hormone, 100 IU/d or 200 IU/d.
MAIN OUTCOME MEASURES. The number of oocytes, total dose of drug used, and pregnancy rates.
RESULTS. Compared with the 20 women receiving 200 IU/d, the 20 who received 100 IU/d had a significantly lower median number of oocytes retrieved and median total dose of drug used (7.5 versus 15.0 [P
CONCLUSIONS. Use of 100 IU/d of recombinant follicle-stimulating hormone requires a lower total dose but results in the harvest of half the number of oocytes compared with when a dosage of 200 IU/d is used.
Key words: Fertilization in vitro; FSH/administration & dosage; Ovulation induction; Pregnancy rate; Recombinant proteins/administration & dosage
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