ABSTRACT

Hong Kong Med J 2000;6:13–23 | Number 1, March 2000
ORIGINAL ARTICLE
Obesity is the key determinant of cardiovascular risk factors in the Hong Kong Chinese population: cross-sectional clinic-based study
ZSK Lee, JAJH Critchley, JCN Chan, PJ Anderson, GN Thomas, GTC Ko, RP Young, TYK Chan, CS Cockram, B Tomlinson
Divisions of Clinical Pharmacology and Endocrinology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
 
 
OBJECTIVES. To examine the interrelationships between obesity and various cardiovascular risk factors, and to investigate the relative importance of insulin and obesity in their associations with various pathophysiologies.
 
DESIGN. Cross-sectional clinic-based study.
 
SETTING. Medical clinics at a university teaching hospital, Shatin, Hong Kong.
 
PARTICIPANTS. A heterogeneous cohort of 767 Hong Kong Chinese subjects with a mean age of 43 (standard deviation, 14) years.
 
MAIN OUTCOME MEASURES. Body mass index, waist circumference, plasma insulin, insulin resistance index, fasting plasma glucose and lipid levels, blood pressure, and 24-hour urinary albumin excretion.
 
RESULTS. Pathophysiological abnormalities and risk factors are frequently clustered to varying degrees. Compared with the control subjects, patients with at least one component of the metabolic syndrome were more obese, hyperinsulinaemic, insulin resistant, hyperglycaemic, hypertensive, dyslipidaemic, and albuminuric (all variables, P/=25 kg/square m, respectively.
 
CONCLUSIONS. Obesity, hyperinsulinaemia, and insulin resistance are characteristic features of Hong Kong Chinese patients who have various components of the metabolic syndrome. Obesity has a greater effect than plasma insulin on various pathophysiologies.
 
Key words: Cardiovascular diseases; Hong Kong; Insulin resistance; Obesity; Risk factors; Syndrome
 
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