Hong Kong Med J 1999;5:9–14 | Number 1, March 1999
The effects of different dosages of oestrogen on the bone mineral density of postmenopausal Hong Kong Chinese women: randomised controlled trial
KY Leung, TK Lee, CN Lee, TK Sum, MYM Chan, CM Tong
Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong
OBJECTIVE. To determine the effects of different dosages of conjugated equine oestrogen on the bone mineral density of postmenopausal Hong Kong Chinese women.
DESIGN. A 1-year three-arm randomised controlled trial.
SETTING. Out-patient setting at a governmental hospital in Hong Kong.
PARTICIPANTS. One hundred and five women aged 45 years or older, in whom menopause had occurred not more than 2 years previously.
INTERVENTION. Women were assigned randomly to treatment with conjugated equine oestrogen 0.625 mg/d or 0.3 mg/d, or no oestrogen.
MAIN OUTCOME MEASURES. Bone mineral density.
RESULTS. Women who were assigned to the control group showed a significant reduction in bone mineral density in both the femoral neck and the lumbar spine (3.6%; P=0.001 and 4.0%; P
CONCLUSION. The minimum effective dosage of conjugated equine oestrogen to prevent osteoporosis in postmenopausal Hong Kong Chinese women is 0.625 mg/d. The bone mineral density, however, was maintained but not increased.
Key words: Bone density; Estrogen replacement therapy; Hong Kong; Osteoporosis, postmenopausal
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