© Hong Kong Academy of Medicine. CC BY-NC-ND 4.0
Recommendations on prevention and screening for breast cancer in Hong Kong
Cancer Expert Working Group on Cancer Prevention and Screening (August 2016 to July 2018)
TH Lam, MD1; KH Wong, MB, BS, FHKAM (Medicine)2; Karen KL Chan, MBBChir, FHKAM (Obstetrics and Gynaecology)3; Miranda CM Chan, MB, BS, FHKAM (Surgery)4; David VK Chao, FRCGP, FHKAM (Family Medicine)5; Annie NY Cheung, MD, FHKAM (Pathology)6; Cecilia YM Fan, MB, BS, FHKAM (Family Medicine)7; Judy Ho, MB, BS, FHKAM (Surgery)8; EP Hui, MD (CUHK), FHKAM (Medicine)9; KO Lam, MB, BS, FHKAM (Radiology)10; CK Law, FHKCR, FHKAM (Radiology)11; WL Law, MS, FHKAM (Surgery)12; Herbert HF Loong, MB, BS, FHKAM (Medicine)13; Roger KC Ngan, FRCR, FHKAM (Radiology)14; Thomas HF Tsang, MB, BS, FHKAM (Community Medicine)15; Martin CS Wong, MD, FHKAM (Family Medicine)16; Rebecca MW Yeung, MD, FHKAM (Radiology)17; Anthony CH Ying, MB, BS, FHKAM (Radiology)18; Regina Ching, MB, BS, FHKAM (Community Medicine)19
1 School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong
2 Department of Health, Hong Kong
3 The Hong Kong College of Obstetricians and Gynaecologists, Hong Kong
4 Hospital Authority (Surgical), Hong Kong
5 The Hong Kong College of Family Physicians, Hong Kong
6 The Hong Kong College of Pathologists, Hong Kong
7 Professional Development and Quality Assurance, Department of Health, Hong Kong
8 World Cancer Research Fund Hong Kong, Hong Kong
9 Hong Kong College of Physicians, Hong Kong
10 Department of Clinical Oncology, The University of Hong Kong, Hong Kong
11 Hong Kong College of Radiologists, Hong Kong
12 The College of Surgeons of Hong Kong, Hong Kong
13 Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong
14 Hong Kong Cancer Registry, Hospital Authority, Hong Kong
15 Hong Kong College of Community Medicine, Hong Kong
16 The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong
17 Hospital Authority (Non-surgical), Hong Kong
18 The Hong Kong Anti-Cancer Society, Hong Kong
19 Centre for Health Protection, Department of Health, Hong Kong
Corresponding author: Dr Regina Ching (email@example.com)
In Hong Kong, breast cancer is the most common cancer among women and poses a significant health care burden. The Cancer Expert Working Group on Cancer Prevention and Screening (CEWG) was set up in 2002 by the Cancer Coordinating Committee to review and assess local and international scientific evidence, and to formulate recommendations for cancer prevention and screening. After considering the local epidemiology, emerging scientific evidence, and local and overseas screening practices, the CEWG concluded that it was unclear whether population-based breast cancer screening did more harm than good in local asymptomatic women at average risk. The CEWG considers that there is insufficient evidence to recommend for or against population-based mammography screening for such individuals. Women who consider breast cancer screening should be adequately informed about the benefits and harms. The CEWG recommends that all women adopt primary preventive measures, be breast aware, and seek timely medical attention for suspicious symptoms. For women at high risk of breast cancer, such as carriers of confirmed BRCA1/2 deleterious mutations and those with a family history of breast cancer, the CEWG recommends that they seek doctor’s advice for annual mammography screening and the age at which the process should commence. Additional annual screening by magnetic resonance imaging is recommended for confirmed BRCA1/2 mutation carriers or women who have undergone radiation therapy to the chest between the age of 10 and 30 years. Women at moderate risk of breast cancer should discuss with doctors the pros and cons of breast cancer screening before making an informed decision about mammography screening every 2 to 3 years.
In Hong Kong, the Cancer Coordinating Committee (CCC) is a high-level committee chaired by the Secretary for Food and Health to steer the direction of work and advice on local strategies for cancer prevention and control. Under the auspices of the CCC, the Cancer Expert Working Group on Cancer Prevention and Screening (CEWG) was set up in 2002 to review local and international scientific evidence, and to assess and formulate local recommendations.
This article describes the local breast cancer burden, preventive measures, as well as the rationale that underlies screening recommendations made by the CEWG that were reaffirmed in September 2017.
Local epidemiology of female breast cancer
Since the early 1990s, breast cancer has become the most common cancer among women in Hong Kong. According to the Hong Kong Cancer Registry,1 there were 3900 newly registered female breast cancer cases in 2015, accounting for 26.1% of all new cancer cases among women. The median age at diagnosis was 56 years. The age-standardised incidence rate (ASIR) of female breast cancer was 58.8 per 100 000 standard population. In addition, 575 new cases of carcinoma in situ of breast cancer (also known as ductal carcinoma in situ [DCIS]) were reported in 2015, and the highest age-specific incidence rate was 33.8 per 100 000 female population at age 70 to 74 years. More than half (66%) of DCIS cases were diagnosed in females aged ≥50 years.
There were 702 registered deaths due to breast cancer in 2016, representing 12.2% of and the third leading cause of female cancer deaths.2 The age-standardised mortality rate (ASMR) of female breast cancer was 10.2 per 100 000 standard population. There has been a rising trend of new cases and deaths of female breast cancer over the past three decades. After adjusting for population ageing, the ASIR has maintained an increasing trend while the ASMR has remained relatively stable. Although the ASIR of female breast cancer has been increasing in Hong Kong, it remained lower than the West (eg, UK or Australia) and some Asian countries (eg, Singapore) in 2012 (Fig3 4 5).
Figure. Comparison of estimated age-standardised incidence and mortality rates of female breast cancer in Hong Kong and other countries3, in 2012
Risk factors for female breast cancer
A range of factors account for woman’s risk of breast cancer, of which family history being a strong known one. Risk increases with degree of relatedness of affected relatives, number of affected relatives, and their age at diagnosis.6 7 8 Having one first-degree relative with breast cancer doubles a woman’s risk while having an affected second-degree relative increases risk by 50%.6 The risk increases especially when the relative has been diagnosed before the age of 50.7
Women with certain deleterious gene mutations are at higher risk of breast cancer. Germline mutations in BRCA1/2 genes are associated with 40% to 90% lifetime risk of breast cancer and are the most common cause of hereditary breast cancer. Other less common gene mutations (eg, TP53, PTEN) are also associated with an increased risk.8 9 10 11 It has been estimated that BRCA1/2 mutations contribute to 5% to 10% of breast cancer cases in western countries.8 10 There are limited data on the prevalence of BRCA mutations in the general population of Hong Kong. Latest findings (as of September 2017) from the Hong Kong Hereditary Breast Cancer Family Registry of 2549 clinically high-risk breast or ovarian cancer patients revealed that BRCA mutation was found in 9.6% of patients, among whom 45.1% were BRCA1 and 54.9% were BRCA2.12 This is noticeably different from patients in western countries where the majority of mutations are of BRCA1. In 2011, the Registry started to employ a four-gene panel including TP53 and PTEN.10 13 Since then, 15 (0.6%) and two (0.08%) patients carrying TP53 and PTEN mutations have been identified, respectively.12
Additional established risk factors for female breast cancer include a history of receiving radiation therapy at a young age, history of breast cancer, ovarian cancer or endometrial cancer, history of benign breast disease (eg, atypical hyperplasia), exposure to exogenous hormones (eg, combined oral contraceptives or hormone replacement therapy), reproductive factors (eg, early menarche or late menopause, nulliparity, late first live birth), alcohol consumption, obesity after menopause, and increasing age.6 8 14 15 16 17 18 19 20 21 22 23 24 25 26 A summary of these risk factors for breast cancer and the magnitude of risk is presented in Table 1.6 11 16 17 18 19 20 21 22 23 24 25 26
Primary prevention and breast awareness
Certain breast cancer risk factors are related to personal lifestyle and behaviour. Women can lower their risk by adopting primary preventive measures such as undertaking moderate-intensity or equivalent aerobic physical activity for at least 150 minutes per week, avoidance of alcohol, maintaining a healthy body weight with body mass index between 18.5 and 22.9 and waist circumference less than 80 cm, bearing children at an earlier age and breastfeeding for a longer duration.8 14 15 17 20 Alcohol is a Group I carcinogen as classified by the International Agency for Research on Cancer (IARC), World Health Organization. There is strong evidence that alcohol can cause, inter alia, female breast cancer. With respect to cancer risk, there is no safe level of alcohol consumption. For women, drinking 10 grams of alcohol per day (eg, 250 mL of beer with 5% alcohol content, a small glass (~100 mL) of red or white wine with 12% alcohol content increases the risk of premenopausal breast cancer by 5% and postmenopausal breast cancer by 9%.20 The higher the intake, the higher the risk, not only of breast cancer but at least six or seven other cancers.14
Symptoms of early breast cancer may not be easily noticed. The CEWG recommends all women to be breast aware, that is, be familiar with the normal look and feel of their breasts and visit the doctor promptly if suspicious symptoms appear, such as presence of a breast or axillary lump, change in skin texture of the breast or nipple, or nipple rash, discharge, or retraction.
Screening for the general female population at average risk
Breast self-examination, clinical breast examination, and mammography are widely used breast cancer screening modalities. The CEWG considers there is insufficient evidence to recommend regular breast self-examination as a screening tool due to its low sensitivity in detecting breast cancer, no proven benefit in reducing breast cancer mortality, and greater harm due to the increased detection of benign lesions and biopsies performed.27 The CEWG is also of the view that there is insufficient evidence to recommend clinical breast examination since its effectiveness in reducing breast cancer mortality cannot be concluded from the limited studies available.28 29 30
Ultrasonography, used as an adjunct to mammography in women with radiologically dense breasts, has the potential to depict small breast cancers not visible on mammography.31 However, both the Cochrane review in 201332 and the IARC review in 20158 33 concluded that there is insufficient evidence that ultrasonography as an adjunct to mammography screening can decrease breast cancer mortality.
Evidence from some western countries suggests that organised breast screening programmes using mammography are effective in the detection of tumours at an earlier stage and reduction of breast cancer mortality in their populations. Nevertheless disadvantages such as false-positive or false-negative results, overdiagnosis (the diagnosis of breast cancer, in particular of DCIS, as a result of screening that would not have been diagnosed or never have caused harm in a patient’s lifetime if screening had not taken place), overtreatment, and potential complications arising from subsequent invasive investigations or treatment may outweigh the benefits.1 34 35
A Cochrane review in 2013 estimated that mammography screening resulted in a 15% reduction in breast cancer mortality and a 30% increase in overdiagnosis and overtreatment. For every 2000 women invited for mammography screening over a 10-year period, one woman would be prevented from dying of breast cancer; 10 healthy women would be treated unnecessarily; and more than 200 women would be falsely alarmed and experience significant psychological distress because of false-positive findings.36
In UK, the Independent Breast Review in 2013 showed that mammography screening led to a relative risk reduction in breast cancer mortality of 20% and an estimated 11% overdiagnosis rate.37
The Swiss Medical Board reported in 2013 that for every 1000 women who underwent regular mammography screening, one to two women’s lives could be saved, but around 100 women would undergo unnecessary investigations and treatment. The cost-effectiveness ratio was very unfavourable. The Board concluded that introduction of a mammography screening programme was not recommended and a time limit should be set on existing programmes. The Board further recommended that thorough medical assessment and comprehensive information about the benefits and harms of screening should be provided to women considering mammography screening.38
The 25-year follow-up of the Canadian National Breast Screening Study in 2014 revealed that women aged 40 to 59 years who underwent annual mammography screening received no benefit in terms of breast cancer mortality but resulted in 22% overdiagnosis, prompting the need of policy-makers to reassess the rationale of screening.34
In 2015, the IARC evaluated the cancer-preventive and adverse effects of different breast cancer screening methods. It was estimated that women aged 50 to 69 years invited for mammography screening had a 24% reduced risk of mortality from breast cancer. Notwithstanding this, the evaluation concluded sufficient evidence that mammography screening led to overdiagnosis at an average rate of 6.5% (range, 1-10%). The estimated cumulative risk of false-positive results was about 20% for a woman who had 10 screens from age 50 to 70 years, leading to short-term negative psychological consequences.8 33
In some regions of Asia where organised mammography screening programmes (eg, Singapore, Korea, Taiwan) are implemented, there is a lack of published peer-reviewed articles in the public domain documenting systematic programme evaluation or modelling studies that estimate or report on the extent of overdiagnosis and the number of lives saved. At the same time, there is evidence of a generally low acceptance of mammography screening in Asian regions. Data kept by the International Cancer Screening Network39 showed that the participation rate of a breast cancer screening programme in 2010 was 19% in Japan and 39.3% in Korea. The Singapore National Health Survey of 2010 showed that 39.6% women aged 50 to 69 years reported a history of mammography according to the recommended screening interval in Singapore, which was within the 2 years preceding the survey.40 In Taiwan, the coverage of mammography screening among women aged 45 to 69 years was 36% in 2012/2013.41
Furthermore, some international and local evidence suggests a reduction in breast cancer mortality could be attributable to improved survival due to treatment advances and improved health service delivery rather than screening per se.35 42 43 44
In Hong Kong, the ASIR of breast cancer is relatively low when compared with that in western countries. Therefore, the positive predictive value of mammography will be lower, generating more false-positive results and ensuing unnecessary follow-up investigations, potential complications and psychological distress.45 Furthermore, local modelling studies have shown that population-based mammography screening is not a cost-effective public health intervention in Hong Kong as compared with other strategies to prevent and control breast cancer.46 47
In conclusion, the CEWG considers that there is so far insufficient evidence to make a definitive recommendation for or against population-based mammography screening for asymptomatic women at average risk in Hong Kong. Individuals considering breast cancer screening should be adequately informed by doctors about the associated benefits and harms.
Screening for women at increased risk
Locally, there is lack of consensus on how to identify women at increased risk of breast cancer. The CEWG has based its conclusions on international studies and overseas practices to derive a local definition of increased risk by adopting a set of qualitative risk stratification criteria, which include BRCA1/2 deleterious mutation carrier status, characteristics of family history and personal risk factors. Women at increased risk are categorised as being at ‘high risk’ or ‘moderate risk’ (Table 2).
Enhanced surveillance for early detection of breast cancer has been suggested as a secondary preventive measure for women at increased risk. Although there has been no randomised controlled trial of mammography screening specifically in women at increased risk, previous observational studies concluded that mammography screening of high-risk population could be effective despite differences in study populations, criteria for risk stratification, screening protocols, and measures of effectiveness.48 49 50 51 Having said that, mammography generally has lower sensitivity in younger women and those with a genetic predisposition to breast cancer due to increased mammographic density obscuring the radiological features of early breast cancer in premenopausal women, and a higher likelihood of benign mammographic images for BRCA-related breast cancer.52
Magnetic resonance imaging has been recommended as an adjunct to routine mammography for surveillance of women at high risk. Magnetic resonance imaging is more sensitive than mammography for detection of breast cancer among BRCA1/2 mutation carriers.53 54 The IARC review found improved sensitivity (95% vs 40%) but lower specificity (80% vs 95%) of MRI plus mammography compared with mammography alone.8
In this regard, several studies have reported that breast cancer screening with MRI in women at increased risk has significantly shifted the stage at diagnosis from advanced stage to earlier and pre-invasive stage, when compared with other common screening modalities such as clinical breast examination, mammography, and ultrasonography.55 56 57 A modelling study of three large BRCA1/2 screening projects in UK, Canada, and the Netherlands demonstrated that screening with mammography and MRI (combined screening) detected relatively more DCIS and smaller invasive cancers in BRCA2 mutation carriers than BRCA1 mutation carriers, resulting in larger reductions in breast cancer mortality that ranged from 41.9% (for mammography alone) to 50.1% (combined screening) for BRCA1 and from 46.8% (for mammography alone) to 61.6% (combined screening) for BRCA2.58
One survival analysis among 959 UK women with high-risk genetic mutations reported that 10-year survival was significantly higher in the MRI-screened carriers of BRCA1/2 mutations (95.3%) compared with unscreened mutation carriers (73.7%). However, the analysis did not show any significant difference in 10-year survival between the combined mammography plus MRI and mammography-only groups.59 The IARC review also found variable all-cause survival results among the reviewed cohort studies in women with BRCA1/2 mutation.8
Notwithstanding the above, studies showed that MRI was superior to mammography in detecting hereditary breast cancer. The radiation risk and false-positive rate of different screening strategies should be considered when making individual screening decisions.60 Regarding the effectiveness of screening Chinese women at higher breast cancer risk, there is currently a lack of local studies on the role and effectiveness of MRI and/or mammography.
Based on the emerging scientific evidence and international screening practices, the CEWG recommends that women at high risk of breast cancer see a doctor and undergo mammography screening every year, starting at age 35 or 10 years prior to the age at diagnosis of the youngest affected relative (for those with a family history), whichever is earlier, but not earlier than age 30. For confirmed carriers of BRCA1/2 deleterious mutations or women who have had radiation therapy to the chest between age 10 and 30 years (eg, for Hodgkin’s disease), the CEWG recommends that they consider additional annual screening by MRI.
Women who have any first-degree female relative with confirmed BRCA1/2 deleterious mutations should be offered genetic testing to confirm or refute their carrier status. Apart from this, for women at high risk due to other types of family history of breast/ovarian cancer (Table 2) who wish to clarify their genetic risk or that of their family, referral to a specialist cancer clinic for advice, counselling and management should be discussed and considered. Genetic testing should be performed by specialised cancer centres with expertise in genetic counselling that should be provided before genetic testing. Health care professionals should discuss with their clients in detail the limitations, uncertainties, and implications of test results.
There exists a group of women whose risk of developing breast cancer may not be as high as those with a genetic mutation or strong family history, but who are at moderate risk due to a family history of breast cancer. The CEWG recommends that women at moderate risk discuss with their doctor the pros and cons of breast cancer screening before deciding whether to start screening by mammography every 2 to 3 years. Magnetic resonance imaging is not recommended for women at moderate risk.
Table 2 summarises the current CEWG recommendations for breast cancer screening in women at average and increased risk. A set of leaflets and a booklet on breast cancer prevention and screening are available (http://www.chp.gov.hk/en/content/9/25/31932.html) to the public to empower informed decision-making.
After taking into consideration the local epidemiology, emerging scientific evidence, and local and overseas screening practices, the CEWG concludes that it is unclear whether breast cancer screening does more harm than good for the asymptomatic woman at average risk, and has reaffirmed that there is insufficient evidence so far to recommend population-based mammography screening for these women. Individuals considering breast cancer screening should discuss the matter with their doctors and be adequately informed about the benefits and harms. Primary prevention, breast awareness, and timely medical attention for suspicious symptoms are recommended for women of any age. The CEWG recommends that women at high risk seek medical advice and counselling about breast cancer screening.
The CEWG will continue to review emerging evidence for or against breast cancer screening and prevention, including the outcome of research commissioned by the Research Office of the Food and Health Bureau at a local institution to develop a validated risk prediction tool for the local population. The findings will facilitate formulation by the CEWG of evidence-based recommendations of criteria for breast cancer screening, especially for those at higher risk.
As editors of this journal, DVK Chao, HHF Loong, and MCS Wong were not involved in the peer review process of this article. All other authors have no conflicts of interest to disclose. All authors had full access to the data, contributed to the study, approved the final version for publication, and take responsibility for its accuracy and integrity. An earlier version of this article was published online in the Centre for Health Protection website, September 2017.
1. Hong Kong Cancer Registry, Hospital Authority. Female Breast Cancer in 2015. Available from: http://www3.ha.org.hk/cancereg/pdf/factsheet/2015/breast_2015.pdf. Accessed 21 Dec 2017.
2. Department of Health, Census and Statistics Department, Hong Kong SAR Government. Mortality statistics in 2016. Available from: https://www.chp.gov.hk/en/healthtopics/content/25/53.html. Accessed 21 Dec 2017.
3. Ervik M, Lam F, Ferlay J, Mery L, Soerjomataram I, Bray F. Cancer today. Lyon, France: International Agency for Research on Cancer. Cancer Today. Available from: http://gco.iarc.fr/today. Accessed 19 Sep 2017.
4. Doll R, Payne P, Waterhouse J. Cancer Incidence in Five Continents: A Technical Report. Berlin: Springer Verlag; 1966.
5. Segi M. Cancer Mortality for Selected Sites in 24 Countries (1950-57). Sendai: Tohoku University School of Public Health; 1960.
6. Pharoah PD, Day NE, Duffy S, Easton DF, Ponder BA. Family history and the risk of breast cancer: a systematic review and meta-analysis. Int J Cancer 1997;71:800-9. CrossRef
7. Kharazmi E, Chen T, Narod S, Sundquist K, Hemminki K. Effect of multiplicity, laterality, and age at onset of breast cancer on familial risk of breast cancer: a nationwide prospective cohort study. Breast Cancer Res Treat 2014;144:185-92. CrossRef
8. International Agency for Research on Cancer. IARC Handbooks of Cancer Prevention. Volume 15: Breast Cancer Screening. France: World Health Organization; 2016.
9. Shiovitz S, Korde LA. Genetics of breast cancer: a topic in evolution. Ann Oncol 2015;26:1291-9. CrossRef
10. Kwong A, Chen JW, Shin VY. A new paradigm of genetic testing for hereditary breast/ovarian cancer. Hong Kong Med J 2016;22:171-7. CrossRef
11. Risch HA, McLaughlin JR, Cole DE, et al. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. J Natl Cancer Inst 2006;98:1694-706. CrossRef
12. Hong Kong Hereditary Breast Cancer Registry. Our Statistics: Analysis of participants recruited into research study till September 2017. Available from: http://www.asiabreastregistry.com/en/hereditary-cancers/our-statistics.Accessed 21 Dec 2017.
13. Kwong A, Shin VY, Au CH, et al. Detection of germline mutation in hereditary breast and/or ovarian cancers by next-generation sequencing on a four-gene panel. J Mol Diagn 2016;18:580-94. CrossRef
14. World Cancer Research Fund. American Institute for Cancer Research. Breast Cancer 2010 Report: Food, nutrition, physical activity, and the prevention of breast cancer. 2010. Available from: http://www.wcrf.org/sites/default/files/Breast-Cancer-2010-Report.pdf. Accessed 19 Sep 2017.
15. International Agency for Research on Cancer, World Health Organization. List of classifications by cancer sites with sufficient or limited evidence in humans. Vol 1-117. Available from: http://monographs.iarc.fr/ENG/Classification/Table4.pdf. Accessed 19 Sep 2017.
16. Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol 2012;13:1141-51. CrossRef
17. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50 302 women with breast cancer and 96 973 women without the disease. Lancet 2002;360:187-95. CrossRef
18. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet 1996;347:1713-27. CrossRef
19. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 1997;350:1047-59. CrossRef
20. World Cancer Research Fund. American Institute for Cancer Research. Continuous update project. Analysing research on cancer prevention and survival. Diet, nutrition, physical activity and breast cancer. 2017. Available from: https://wcrf.org/sites/default/files/Breast-Cancer-2017-Report.pdf. Accessed 19 Sep 2017.
21. Anderson WF, Pfeiffer RM, Dores GM, Sherman ME. Comparison of age distribution patterns for different histopathologic types of breast carcinoma. Cancer Epidemiol Biomarkers Prev 2006;15:1899-905. CrossRef
22. Hartmann LC, Sellers TA, Frost MH, et al. Benign breast disease and the risk of breast cancer. N Engl J Med 2005;353:229-37. CrossRef
23. Travis LB, Hill DA, Dores GM, et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 2003;290:465-75. CrossRef
24. Singletary SE. Rating the risk factors for breast cancer. Ann Surg 2003;237:474-82. CrossRef
25. Brinton LA, Hoover R, Fraumeni JF, Jr. Reproductive factors in the aetiology of breast cancer. Br J Cancer 1983;47:757-62.
26. Robinson D, Holmberg L, Møller H. The occurrence of invasive cancers following a diagnosis of breast carcinoma in situ. Br J Cancer 2008;99:611-5. CrossRef
27. Kösters JP, Gøtzsche PC. Regular self-examination or clinical examination for early detection of breast cancer. Cochrane Database Syst Rev 2003;(2):CD003373. CrossRef
28. Mittra I, Mishra GA, Singh S, et al. A cluster randomized, controlled trial of breast and cervix cancer screening in Mumbai, India: methodology and interim results after three rounds of screening. Int J Cancer 2010;126:976-84. CrossRef
29. Pisani P, Parkin DM, Ngelangel C, et al. Outcome of screening by clinical examination of the breast in a trial in the Philippines. Int J Cancer 2006;118:149-54. CrossRef
30. Sankaranarayanan R, Ramadas K, Thara S, et al. Clinical breast examination: preliminary results from a cluster randomized controlled trial in India. J Natl Cancer Inst 2011;103:1476-80. CrossRef
31. Ohuchi N, Suzuki A, Sobue T, et al. Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet 2016;387:341-8. CrossRef
32. Gartlehner G, Thaler K, Chapman A, et al. Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk. Cochrane Database Syst Rev 2013;(4):CD009632. CrossRef
33. Lauby-Secretan B, Scoccianti C, Loomis D, et al. Breast-cancer screening—viewpoint of the IARC Working Group. N Engl J Med 2015;372:2353-8. CrossRef
34. Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA. Twenty five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ 2014;348:g366. CrossRef
35. Autier P, Boniol M, Gavin A, Vatten LJ. Breast cancer mortality in neighbouring European countries with different levels of screening but similar access to treatment: trend analysis of WHO mortality database. BMJ 2011;343:d4411. CrossRef
36. Gøtzsche PC, Jørgensen KJ. Screening for breast cancer with mammography. Cochrane Database Syst Rev 2013;(6):CD001877. CrossRef
37. Marmot MG, Altman DG, Cameron DA, Dewar JA, Thompson SG, Wilcox M. The benefits and harms of breast cancer screening: an independent review. Br J Cancer 2013;108:2205-40. CrossRef
38. Swiss Medical Board. Systematic mammography screening. December 2013. Available from: http://www.medical-board.ch/fileadmin/docs/public/mb/fachberichte/2013-12-15_bericht_mammographie_final_kurzfassung_e.pdf. Accessed 19 Sep 2017.
39. National Cancer Institute. International Cancer Screening Network. Breast cancer screening programs in 26 ICSN Countries, 2012: organization, policies, and program reach. December 2016. Available from: https://healthcaredelivery.cancer.gov/icsn/breast/screening.html. Accessed 31 Jan 2018.
40. Epidemiology and Disease Control Division. Singapore Ministry of Health. National Health Survey 2010. Available from: https://www.moh.gov.sg/content/dam/moh_web/Publications/Reports/2011/NHS2010%20-%20low%20res.pdf. Accessed 31 Jan 2018.
41. Health Promotion Administration, Taiwan Ministry of Health and Welfare. Breast cancer screening rate: Percentage of women aged 45-69 reporting a mammography in the past 2 years. Available from: http://126.96.36.199/dataset/143070580718. Accessed 31 Jan 2018.
42. Jørgensen KJ, Zahl PH, Gøtzsche PC. Breast cancer mortality in organised mammography screening in Denmark: comparative study. BMJ 2010;340:c1241. CrossRef
43. Wong IO, Schooling CM, Cowling BJ, Leung GM. Breast cancer incidence and mortality in a transitioning Chinese population: current and future trends. Br J Cancer 2015;112:167-70. CrossRef
44. Kalager M, Zelen M, Langmark F, Adami HO. Effect of screening mammography on breast-cancer mortality in Norway. N Engl J Med 2010;363:1203-10. CrossRef
45. Lui CY, Lam HS, Chan LK, et al. Opportunistic breast cancer screening in Hong Kong; a revisit of the Kwong Wah Hospital experience. Hong Kong Med J 2007;13:106-13.
46. Wong IO, Kuntz KM, Cowling BJ, Lam CL, Leung GM. Cost-effectiveness analysis of mammography screening in Hong Kong Chinese using state-transition Markov modelling. Hong Kong Med J 2010;16 Suppl 3:38-41.
47. Wong IO, Tsang JW, Cowling BJ, Leung GM. Optimizing resource allocation for breast cancer prevention and care among Hong Kong Chinese women. Cancer 2012;118:4394-403. CrossRef
48. Maurice A, Evans DG, Shenton A, et al. Screening younger women with a family history of breast cancer—does early detection improve outcome? Eur J Cancer 2006;42:1385-90. CrossRef
49. Kerlikowske K, Carney PA, Geller B, et al. Performance of screening mammography among women with and without a first-degree relative with breast cancer. Ann Intern Med 2000;133:855-63. CrossRef
50. Gui GP, Kadayaprath G, Darhouse N, et al. Clinical outcome and service implications of screening women at increased breast cancer risk from a family history. Eur J Surg Oncol 2006;32:719-24. CrossRef
51. Cortesi L, Turchetti D, Marchi I, et al. Breast cancer screening in women at increased risk according to different family histories: an update of the Modena Study Group experience. BMC Cancer 2006;6:210. CrossRef
52. Lord SJ, Lei W, Craft P, et al. A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer. Eur J Cancer 2007;43:1905-17. CrossRef
53. Warner E, Messersmith H, Causer P, Eisen A, Shumak R, Plewes D. Systematic review: using magnetic resonance imaging to screen women at high risk for breast cancer. Ann Intern Med 2008;148:671-9. CrossRef
54. Passaperuma K, Warner E, Causer PA, et al. Long-term results of screening with magnetic resonance imaging in women with BRCA mutations. Br J Cancer 2012;107:24-30. CrossRef
55. Kuhl C, Weigel S, Schrading S, et al. Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trial. J Clin Oncol 2010;28:1450-7. CrossRef
56. Sardanelli F, Podo F, Santoro F, et al. Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (the high breast cancer risk italian 1 study): final results. Invest Radiol 2011;46:94-105. CrossRef
57. Warner E, Hill K, Causer P, et al. Prospective study of breast cancer incidence in women with a BRCA1 or BRCA2 mutation under surveillance with and without magnetic resonance imaging. J Clin Oncol 2011;29:1664-9. CrossRef
58. Heijnsdijk EA, Warner E, Gilbert FJ, et al. Differences in natural history between breast cancers in BRCA1 and BRCA2 mutation carriers and effects of MRI screening-MRISC, MARIBS, and Canadian studies combined. Cancer Epidemiol Biomarkers Prev 2012;21:1458-68. CrossRef
59. Evans DG, Kesavan N, Lim Y, et al. MRI breast screening in high-risk women: cancer detection and survival analysis. Breast Cancer Res Treat 2014;145:663-72. CrossRef
60. Lowry KP, Lee JM, Kong CY, et al. Annual screening strategies in BRCA1 and BRCA2 gene mutation carriers: a comparative effectiveness analysis. Cancer 2012;118:2021-30. CrossRef