Inhibition of RIG-I-dependent innate immunity by herpes simplex virus type I Us11 protein
C Kew, PY Lui, CP Chan, DY Jin, KH Kok
Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong
1. Double-stranded RNA binding protein PACT activates RIG-I and thus optimally induces the production of type I interferon.
2. PACT associates with RIG-I in virus-infected cells. Activation of RIG-I by PACT triggers host anti-viral responses.
3. Herpes simplex virus 1 (HSV-1)-encoded Us11 protein inhibits the production of type I interferon in virus-infected cells. Mutant HSV-1 virus incapable of expressing Us11 protein induces higher amounts of type I interferon.
4. Us11 associates with PACT, and inhibits PACT-dependent type I interferon production.
5. Other viruses may apply the same strategy to shut down host antiviral responses by inhibiting PACT-dependent type I interferon production.
2. PACT associates with RIG-I in virus-infected cells. Activation of RIG-I by PACT triggers host anti-viral responses.
3. Herpes simplex virus 1 (HSV-1)-encoded Us11 protein inhibits the production of type I interferon in virus-infected cells. Mutant HSV-1 virus incapable of expressing Us11 protein induces higher amounts of type I interferon.
4. Us11 associates with PACT, and inhibits PACT-dependent type I interferon production.
5. Other viruses may apply the same strategy to shut down host antiviral responses by inhibiting PACT-dependent type I interferon production.