Hong Kong Med J 2015;21(Suppl 4):S39-44
Modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis
LYF Wong, BMY Cheung
Department of Medicine, The University of Hong Kong
1. Adrenomedullin augments the production of interleukin-10, a cytokine that limits inflammation.
2. Interferon-γ, a cytokine that is increased in inflammation, downregulates the receptor and binding protein of adrenomedullin.
3. Cyclic AMP mediates the increased expression of adrenomedullin, interleukin-6, and interleukin-10 in response to endotoxin.
4. The production of interleukin-6 is mediated by p38-mitogen-activated protein kinase (MAPK), p42/44-MAPK, protein kinase C, and protein kinase K, whereas that of interleukin-10 is mediated by p38-MAPK and protein kinase K.
5. These downstream pathways could be targets for therapeutic intervention.
2. Interferon-γ, a cytokine that is increased in inflammation, downregulates the receptor and binding protein of adrenomedullin.
3. Cyclic AMP mediates the increased expression of adrenomedullin, interleukin-6, and interleukin-10 in response to endotoxin.
4. The production of interleukin-6 is mediated by p38-mitogen-activated protein kinase (MAPK), p42/44-MAPK, protein kinase C, and protein kinase K, whereas that of interleukin-10 is mediated by p38-MAPK and protein kinase K.
5. These downstream pathways could be targets for therapeutic intervention.