Hong Kong Med J 2015;21(Suppl 4):S27-30
Role of hepatitis B virus X protein in liver cancer
IOL Ng, KMF Sze, GKY Chu
Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
1. Full-length HBx and two natural C-terminal truncated HBx mutants (1-130 and 1-119 amino acid residues) do not alter the mitotic checkpoint control in hepatocytes or deregulate the expression of mitotic checkpoint proteins in hepatocellular carcinoma (HCC) cells.
2. The inducible gene expression systems are useful tools to characterise the role of HBx protein in human HCC.