Hong Kong Med J 2014;20(Suppl 6):S7-10
Avian influenza A H5N1 infection on human cellular microRNA profile: identification of gene regulatory pathway
PKS Chan, KF To, WY Lam
Department of Microbiology, The Chinese University of Hong Kong
1. Based on the broad-catching microRNA (miRNA) microarray approach, dysregulation of miRNA expression is mainly observed in highly pathogenic avian influenza A (H5N1) virus infection.
2. miRNA 141 (miR-141) was induced shortly after influenza A (H1N1) virus infection. Induction was greater in H5N1 infection than in seasonal H1N1 infection.
3. A cytokine, transforming growth factor-_2, which plays an important role in regulating inflammatory processes, was identified as a target of miR-141 binding. This suggests that influenza A virus infection, in particular highly pathogenic H5N1, can affect the inflammatory processes via miR-141 induction.