Hong Kong Med J 2014;20(Suppl 6):S44-7
Integrated human papillomavirus analysis as an adjunct for triage of atypical cervical cytology
ANY Cheung, OG Wong, KKY Chan, MS Yang, CH Tsang, SL Ji, CK Lo, E Szeto, E Wong, HYS Ngan
Department of Pathology, The University of Hong Kong, Queen Mary Hospital
1. Human papillomavirus (HPV) genotyping, HPV type-specific E6/E7 transcript detection, and hTERT transcript detection could improve the specificity of predicting subsequent development of squamous intraepithelial lesions, compared with cocktail HPV DNA detection alone.
2. The correlation between HPV RNA and hTERT expression supports their interactive role in the development of cervical cancer and precursor lesions.
3. Prophylactic HPV vaccines, besides protecting against cervical cancer, can also reduce the burden of screening for those with atypical squamous cells of undetermined significance.