Hong Kong Med J 2014;20(Suppl 6):S11-5
Role of toll-like receptors in naturally occurring influenza virus infection
NLS Lee, CK Wong, DSC Hui, PKS Chan
Department of Medicine and Therapeutics, The Chinese University of Hong Kong
1. In naturally occurring influenza virus infection, there is differential increase in toll-like receptor (TLR) expression in antigen-presenting cells.
2. Increased TLR expression is associated with early innate suppression of virus, reducing influenza viral loads.
3. Concomitantly, TLR signalling induces pro- inflammatory and adaptive cytokine responses.
4. Targeting of TLRs may be a novel strategy to improve influenza control.