Hong Kong Med J 2013;19(Suppl 5):S31-5
Identification of Epstein-Barr virus microRNA in nasopharyngeal carcinoma cells
RWM Lung, JHM Tong, MYM Sung, SL Chau, KW Lo, KF To
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong
1. The first small RNA library from Epstein-Barr virus (EBV) positive nasopharyngeal carcinoma (NPC) cells is constructed.
2. The large proportion of EBV- encoded microRNA (miRNA) compared to cellular miRNA in NPC cells underscores their significance in the establishment and/or maintenance of latent infections and pathogenesis in NPC cells.
3. The two newly identified EBV-encoded miRNAs, ebv- miR-BART-HK1 and ebv- miR-BART-HK2, are now published in www.mirbase. org and named ebv-miR- BART22 (MIMAT0010132) and ebv-miR-BART21-5p (MIMAT0010130), respectively.