Hong Kong Med J 2011;17:407-9 | Number 5, October 2011
Severe community-acquired pneumonia caused by macrolide-resistant Mycoplasma pneumoniae in a 6-year-old boy
David C Lung, YH Chan, L Kwong, TL Que
Department of Clinical Pathology, Tuen Mun Hospital, Tuen Mun, Hong Kong
Mycoplasma pneumoniae is the commonest agent causing atypical pneumonia in children. Macrolides have long been used in the treatment of community-acquired pneumonia not responsive to beta-lactams alone. In this report, we describe the first locally acquired paediatric patient with severe community-acquired pneumonia caused by macrolideresistant Mycoplasma pneumoniae, possessing an A-to-G transition at position 2063 of the 23s rRNA gene. In addition, we have detected two more strains of macrolide-resistant Mycoplasma pneumoniae out of a total of 10 cases with chest infection that were confirmed by polymerase chain reaction. Therefore macrolide-resistant Mycoplasma pneumoniae accounted for 33% (3 out of 10 patients) of the polymerase chain reaction–confirmed cases.
Key words: Community-acquired infections; Doxycycline; Drug resistance, bacterial; Macrolides; Mycoplasma pneumoniae
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