Hong Kong Med J 2010;16:378–82 | Number 5, October 2010
Impact of delayed graft function on renal function and graft survival in deceased kidney transplantation
CY Cheung, HW Chan, YH Chan, KF Chau, CS Li
Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Hong Kong
OBJECTIVES. To define the risk factors for delayed graft function and study the impact of such delays on renal function and long-term allograft survival in renal transplant recipients.
DESIGN. Single-centre retrospective study.
SETTING. Regional hospital, Hong Kong.
PATIENTS. Records of 118 Chinese renal transplant recipients from 1 July 1997 to 31 July 2005 were reviewed, and categorised into delayed and immediate graft function groups.
RESULTS. Delayed graft function was observed in about 19% of patients, for which cold ischaemic time was an important independent predictor. For each additional hour of cold ischaemic time, the odds ratio increased for delayed function by 0.002 (95% confidence interval, 0.001-0.003; P=0.03). Multivariate analysis revealed that neither cold ischaemic time nor delayed graft function was associated with acute rejection. On the other hand, at 1 year both delayed graft function (odds ratio=18.5; 95% confidence interval, 2.6-130.5; P=0.003) and donor age (1.2; 1.1-1.3; P=0.003) were related to a glomerular filtration rate of less than 30 mL/min. When renal function between patients with and without delayed graft function during the first 3 years was compared, it was significantly better in those without delayed graft function. However, there was no significant difference in death-censored graft survival between delayed graft function and immediate graft function groups.
CONCLUSIONS. Delayed graft function has a significant adverse effect on graft function at 1 year. Limiting cold ischaemic time is important as it is an independent predictor of delayed graft function.
Key words: Cold ischemia; Graft rejection; Graft survival; Kidney transplantation; Treatment outcome
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