Hong Kong Med J 2009;15:394-6 | Number 5, October 2009
Possible olanzapine-induced hepatotoxicity in a young Chinese patient
SY Lui, Steve Tso, M Lam, Eric FC Cheung
Castle Peak Hospital, Tuen Mun, Hong Kong
We present a case of a 17-year-old man with first-episode schizophrenia who developed olanzapine-induced hepatitis, cholestasis, and splenomegaly, all of which were reversed after ceasing olanzapine. Clinicians prescribing olanzapine should be aware of this possible hepatotoxicity. Patient education, vigilance from clinicians, and careful clinical examination can help detect this complication early.
Key words: Antipsychotic agents; Hepatitis, toxic; Jaundice; Schizophrenia; Splenomegaly
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