Hong Kong Med J 2026;32(Suppl 1):S46-7
Epstein-Barr virus–specific T cell and NK cell responses in paediatric patients with infectious mononucleosis or post-transplant lymphoproliferative disorder: abridged secondary publication
AKS Chiang
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China
 
 
  1. In patients with post-transplant lymphoproliferative disorder (PTLD), Epstein-Barr virus (EBV)-specific CD8+ polyfunctional T cells were limited at 24 months after diagnosis, despite clinical remission.
  2. In patients with PTLD, the frequency of potent degranulating CD56dimNKG2A+KIR− NK cells diminished from diagnosis to clinical remission.
  3. In patients with PTLD, plasma EBV viral loads were weakly correlated with blood tacrolimus levels. Prolonged immunosuppression may result in suboptimal immune control of EBV.