Combined use of Andrographis paniculata and
chemotherapeutics for metastatic oesophageal cancer: a pre-clinical study
L Li1; GGL Yue2; KP Fung2,3;
J Yu4; CBS Lau2; PWY Chiu1
1 Department of Surgery, The Chinese
University of Hong Kong
2 Institute of Chinese Medicine and
State Key Laboratory of Bioactivities and Clinical Applications of
Medicinal Plants, The Chinese University of Hong Kong
3 School of Biomedical Sciences, The
Chinese University of Hong Kong
4 Department of Medicine and
Therapeutics, The Chinese University of Hong Kong
1. The combined use of water extract of Andrographis
paniculata (APW) and chemotherapeutics (cisplatin plus
5-fluorouracil) reduced the metastasis of oesophageal tumour to lung in
mouse models.
2. The combined use of APW and chemotherapeutics significantly suppressed the oesophageal xenograft growth by enhancing apoptosis.
3. Combined use of APW and chemotherapeutics had additional immunomodulatory benefit of APW.
4. The absorbed components of APW possessed anti-migratory activities in oesophageal cancer cells.
2. The combined use of APW and chemotherapeutics significantly suppressed the oesophageal xenograft growth by enhancing apoptosis.
3. Combined use of APW and chemotherapeutics had additional immunomodulatory benefit of APW.
4. The absorbed components of APW possessed anti-migratory activities in oesophageal cancer cells.