Hong Kong Med J 1999;5:233–9 | Number 3, September 1999
Evaluation of the ThinPrep Papanicolaou test in clinical practice: 6-month study of 16 541 cases with histological correlation in 220 cases
GPS Yeoh, KW Chan, I Lauder, MB Lam
Diagnostix Pathology Laboratories, Canossa Hospital, 1 Old Peak Road, Hong Kong
OBJECTIVE. To evaluate the liquid-based ThinPrep Papanicolaou test.
DESIGN. Prospective comparison of the ThinPrep test with the conventional Papanicolaou test.
SETTING. Cervical smear specimens sent to a private practice, Hong Kong.
PATIENTS. A total of 16 541 ThinPrep test specimens and 7258 conventional Papanicolaou smears from Hong Kong women who had been screened for cervical cancer between mid-July 1998 and mid-January 1999.
MAIN OUTCOME MEASURES. Specimen adequacy, endocervical cell content, epithelial cell abnormalities, and micro-organisms present in both types of cervical smears; histological diagnosis of cervical biopsy specimens of women who had the ThinPrep test.
RESULTS. Compared with the conventional Papanicolaou smear test, the ThinPrep test showed a reduction in the frequency of ‘unsatisfactory’ (0.56% versus 1.36%; P
CONCLUSIONS. The ThinPrep test has high a sensitivity and positive predictive value. The ThinPrep test gives higher-quality specimens and has a higher detection rate of squamous intraepithelial lesions than does the conventional Papanicolaou smear test. The drawbacks of the liquid-based system, however, pertain to cost and the additional procedures and training needed.
Key words: Cervical intraepithelial neoplasia; Cervix neoplasms; Cytological techniques; Laboratory techniques and procedures; Vaginal smears/methods
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