Hong Kong Med J 2026;32(Suppl 1):S31-4
Fine needle biopsy guided by contrast-enhanced harmonic versus conventional endoscopic ultrasound with macroscopic on-site evaluation for solid pancreatic lesions: abridged secondary publication
CCN Chong1, D Ligresti2, TH Kim3, I Tarantino2, M Traina2, R Liotta4, PCT Ip1, HT Lok1, AKY Fung1, JWC Kung1, EYJ Lo1, MTL Wong5, TT Chan5, JCT Lai5, HHW Leung6, F Sia7, KW Yau7, AYB Teoh1, KKC Ng1, KF To6, PWY Chiu1, RSY Tang5,7
1 Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China
2 Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS - ISMETT, Palermo, Italy
3 Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea
4 Pathology Unit, Department of Diagnostic and Therapeutic Services, IRCCS - ISMETT, Palermo, Italy
5 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China
6 Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
7 State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China
 
 
  1. Fine needle biopsy guided by either contrast-enhanced harmonic or conventional endoscopic ultrasound, with macroscopic on-site evaluation of specimen adequacy, achieves similarly low false-negative rates and high diagnostic accuracies when the prevalence of avascular areas in lesions is <31%.
  2. Routine use of contrast-enhanced harmonic endoscopic ultrasound for fine needle biopsy may be unnecessary when dedicated needles are used for tissue acquisition and the expected prevalence of avascular areas is low in target lesions.