Role of microRNAs in sight-threatening diabetic
retinopathy in Chinese patients: abridged secondary publication
YY Cheung1,2, CH Lee1,2, DTW Lui1, CHY Fong1, VSY Cheung1, JHC Mak1, RLC Wong1, WS Chow1, YC Woo1,
A Xu1,2, PC Sham3, KSL Lam1,2
1 Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China
2 State Key Laboratory of Pharmaceutical Biotechnology, The University of
Hong Kong, Hong Kong SAR, China
3 Department of Psychiatry, School of Clinical Medicine, The University of
Hong Kong, Hong Kong SAR, China
- MicroRNA-related single nucleotide polymorphisms showed suggestive associations with sight-threatening diabetic retinopathy (STDR) in Chinese patients with type 2 diabetes.
- MicroRNA profiling analysis identified several microRNAs that were differentially expressed between incident STDR cases and non-STDR controls.
- Circulating microRNAs demonstrated the potential to serve as non-invasive biomarkers for prediction of STDR development.
- Independent validation studies are required to confirm the findings of this study.