Berberine suppresses metastasis and recurrence of hepatocellular carcinoma by targeting circulating tumour cells: abridged secondary publication
CS Cheng1; HY Tan1; C Zhang1; YT Chan1; ZJ Zhang1; K Man2; MF Yuen3; N Wang1; Y Feng1
1 School of Chinese Medicine, The University of Hong Kong
2 Department of Surgery, The University of Hong Kong
3 Department of Medicine, The University of Hong Kong
1. In mice with hepatocellular carcinoma with and without surgical resection, a combination of berberine and sorafenib potently improved the therapeutic efficacy and outcome without major adverse effects.
2. In our mouse model, berberine suppressed the in vitro viability and presentation of CD44+EpCAM+ circulating tumour cells (CTCs), as berberine is associated with inhibition of the invasiveness and re-attachment of CTCs and induction of cell apoptosis.
3. The inhibitory effect of berberine on CTCs was due to suppressed expression of CD44 and epithelial-mesenchymal transition pathways in CTCs.