Combination of atorvastatin or hydrochlorothiazide/amlodipine with Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) for atherosclerosis, hyperlipidaemia, and hypertension: a preclinical in vivo study (abridged secondary publication)
DWS Cheung1, JCM Koon2,3, PH Wong1, KC Yau1, ECL Wat2,3, JYW Chan2,3,4, VKM Lau2,3, ECH Ko2,3, MMY Waye1,4,5, KP Fung1,2,6
1 School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
2 Institute of Chinese Medicine, The Chinese University of Hong Kong
3 State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong
4 The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong
5 The Croucher Laboratory for Human Genomics, The Chinese University of Hong Kong
6 School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong
 
 
1. Water extract of Danshen and Gegen (DG) was found to be a potent alternative medicine for atherosclerosis, hyperlipidaemia, and hypertension.
2. Combination of DG and atorvastatin could prevent atherosclerosis and reduce hyperlipidaemia.
3. Combination of DG and hydrochlorothiazide/amlodipine could ameliorate hypertension.
4. DG could help to attenuate adverse effects resulting from atorvastatin or hydrochlorothiazide/amlodipine medication.