Inflammatory properties of ribosome-inactivating protein momorcharin derived from bitter melon: abridged secondary publication
YJ Chen, ZL Yu, AKW Tse
School of Chinese Medicine, Hong Kong Baptist University
1. The inflammatory responses induced by alpha-momorcharin (α-MMC) derived from Momordica charantia (bitter melon) were studied.
2. α-MMC induced cytokines release in human monocytic THP-1 cells.
3. α-MMC-induced inflammatory gene expression were mediated by activation of IKK-NF-κB and JNK pathways.
4. α-MMC induced inflammatory responses in vivo.