Danshen Gegen capsule for intermittent
claudication in patients with peripheral arterial
disease: abridged secondary publication
BPY Yan1, KP Fung2,3, P Chook4, JCM Koon2, JYW Chan2
1 Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong
2 Institute of Chinese Medicine, The Chinese University of Hong Kong
3 School of Biomedical Sciences, The Chinese University of Hong Kong
4 Centre for Clinical Trials on Chinese Medicine, Institute of Chinese Medicine, The Chinese University of Hong Kong
1. We demonstrated in vitro dose-dependent
vasodilation and angiogenesis responses
to Danshen and Gegen via endotheliumindependent
mechanism and involvement
of inwardly rectifying K+ channels and Ca2+
channels.
2. We demonstrated an in vivo effect in functional limb recovery and in vitro improvement in blood micro-vessel density and blood perfusion responses to Danshen and Gegen in a limb ischaemic animal model.
3. Danshen and Gegen may be an effective treatment for patients with intermittent claudication, especially for those with severe symptoms compared with placebo. However, longer-term research in a larger population is needed to deteremine its safety and efficacy.
2. We demonstrated an in vivo effect in functional limb recovery and in vitro improvement in blood micro-vessel density and blood perfusion responses to Danshen and Gegen in a limb ischaemic animal model.
3. Danshen and Gegen may be an effective treatment for patients with intermittent claudication, especially for those with severe symptoms compared with placebo. However, longer-term research in a larger population is needed to deteremine its safety and efficacy.