Role of HP1076 in type IV secretion pathway in Helicobacter pylori: abridged secondary publication
WL Lam1; M Li2; KF Lau1; VSF Chan2; SWN Au1
1 School of Life Sciences, The Chinese University of Hong Kong, Hong Kong
2 Department of Medicine, The University of Hong Kong, Hong Kong
1. Helicobacter pylori HP1076 is essential for translocation and phosphorylation of CagA.
2. Deletion of HP1076 inhibits transcription of CagD and also affects the assembly of Cag T4SS components CagT and CagM.
3. It is likely that the effects of HP1076 on cag T4SS assembly and activity are mediated by down-regulation of CagD.