Involvement of autophagy in antibacterial actions of vitamin D in Helicobacter pylori infection: abridged secondary publication
W Hu1; L Zhang1,2; WKK Wu1,2; CH Cho3,4
1 Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong
2 Institute of Digestive Diseases, State Key Laboratory of Digestive Diseases, LKS Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong
3 School of Biomedical Science, The Chinese University of Hong Kong, Hong Kong
4 Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China
1. We identified a unique pathogenic mechanism on how Helicobacter pylori can survive by hiding inside the autophagosomes in cells.
2. We discovered a novel antibacterial signalling pathway of VD3 through the activation of PDIA3/STAT3 - MCOLN3 - Ca2+ axis, to reactivate the lysosomal acidification and degradation function of autolysosomes, which is the key signal pathway for the antibacterial action of VD3 both in cells and in animals and perhaps further in humans.